Table 2 Multivariable analysis of Clinical predictors of treatment failure among adults living with HIV in Asmara Hospital Follow-up Clinics, Asmara, Eritrea (2001–2020)
Variables | Case vs Controls | |||
|---|---|---|---|---|
cOR (95% CI) | P value | aOR (95% CI) | P value | |
NRTI | ||||
TDF + FTC | 1 | < 0.001 | 1 | < 0.001 |
AZT + 3TC | 2.41(1.40–4.16) | 0.002 | 2.70(1.65–4.41) | < 0.001 |
ABC + 3TC | 4.38(1.10–17.51) | 0.037 | 4.73(1.18–18.92) | 0.028 |
D4T + 3TC | 4.07(2.2.12–7.79) | < 0.001 | 5.00(3.03–8.20) | < 0.001 |
Prior exposure to ART | ||||
No | 1 | 0.115 | 1 | 0.002 |
Yes | 1.78(0.87–3.64) | 2.28(1.35–3.86) | ||
Care entry point | ||||
VCT | 1 | 0.426 | ||
In patient | 0.749 (0.38–1.48) | 0.749 | ||
Medical OPD | 1.11 (0.76–1.61) | 0.380 | ||
Others | 1.61 (0.81–3.18) | 0.155 | ||
Transfer in | 1.62 (0.66–3.95) | 0.291 | ||
NNRTI | ||||
EFV | 1 | 0.310 | ||
NVP | 1.25 (0.81–1.94) | |||
Record of Sub-optimal Drug adherence | ||||
No | 1 | < 0.001 | 1 | < 0.001 |
Yes | 3.06 (2.20–4.26) | 3.08 (2.22–4.28) | ||
Baseline functional Status | ||||
Working | 1 | 0.010 | 1 | 0.010 |
Ambulatory/Bed-ridden | 1.63 (1.12–2.37) | 1.61 (1.12–2.31) | ||
Any comorbidities | ||||
No | 1 | 0.001 | 1 | 0.002 |
Yes | 2.55 (1.46–4.45) | 2.37 (1.36–4.10) | ||
Duration of cART | ||||
> 5 years | 1 | < 0.001 | 1 | < 0.001 |
< 5 years | 5.93 (3.95–8.90) | 5.90 (3.95–8.73) | ||
SMX TMP | ||||
No | 1 | < 0.001 | 1 | < 0.001 |
Yes | 2.01 (1.44–2.81) | 2.00 (1.44–2.78) | ||
Baseline CD4 + cell count | ||||
< 50 cells/ µl | 1 | 0.039 | 1 | 0.039 |
> 50–100 cells/ µl | 1.91 (1.11–3.26) | 0.019 | 1.92 (1.12–3.28) | 0.017 |
> 100–200 cells/ µl | 1.05 (0.63–1.72) | 0.974 | 1.07 (0.65–1.76) | 0.787 |
> 200–350 cells/ µl | 1.55 (0.91–2.20) | 0.305 | 1.57 (0.929–2.66) | 0.092 |
> 350 cells/ µl | 1.13 (0.58–2.20) | 0.992 | 1.12 (0.57–2.18) | 0.745 |
The duration between diagnosis and initiation of cART | 0.992 (0.986–1.00) | 0.007 | 0.992 (0.986–1.00) | 0.006 |