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Table 2 Comparison of outcomes and treatments during Delta, Delta to Omicron, and Omicron periods, adjusted for age, gender, and Elixhauser comorbidity index

From: Characteristics and outcomes of COVID-19 patients during B.1.1.529 (Omicron) dominance compared to B.1.617.2 (Delta) in 89 German hospitals

 

Total

SARI-

SARI+

Cohort

Proportion ( n )

Odds ratio (95% CI)

P value

Proportion ( n )

Odds ratio (95% CI)

P value

Proportion ( n )

Odds ratio (95% CI)

P value

Intensive care treatment

Delta

16.6% (275)

  

8.3% (49)

  

21.2% (226)

  

Delta to Omicron

16.2% (177)

1.14 (0.91–1.42)

0.257

10.9% (57)

1.55 (1.00-2.39)

0.049

21.1% (120)

1.11 (0.85–1.46)

0.435

Omicron

9.5% (167)

0.72 (0.57–0.91)

0.005

7.2% (88)

1.16 (0.78–1.74)

0.466

14.8% (79)

0.73 (0.54-1.00)

0.050

Mechanical ventilation

Delta

12.2% (202)

  

1.0% (6)

  

18.4% (196)

  

Delta to Omicron

10.8% (118)

1.04 (0.81–1.34)

0.770

0.8% (4)

0.83 (0.23-3.00)

0.782

20.0% (114)

1.28 (0.97–1.69)

0.079

Omicron

4.0% (70)

0.42 (0.31–0.57)

< 0.001

0.9% (11)

1.16 (0.42–3.21)

0.776

11.0% (59)

0.62 (0.44–0.87)

0.006

In-hospital mortality*

Delta

16.3% (254)

  

3.9% (22)

  

23.4% (232)

  

Delta to Omicron

12.2% (126)

0.90 (0.70–1.17)

0.437

2.8% (14)

0.95 (0.46–1.94)

0.885

21.1% (112)

1.02 (0.76–1.36)

0.915

Omicron

5.5% (94)

0.42 (0.32–0.56)

< 0.001

1.1% (13)

0.43 (0.21–0.88)

0.021

15.7% (81)

0.63 (0.45–0.87)

0.005

  1. *based on 4,286 cases (95.4%). We excluded cases with discharge due to hospital transfer or unspecified reason. CI = Confidence interval; SARI = Severe Acute Respiratory Infection