| Hospitalized patients (admitted between 1/3/2021–28/3/2022) with available variant information (confirmed by WGSa) from baseline surveillance (n = 1767) | Hospitalized patients (admitted between 1/3/2021–28/3/2022) without any available variant information (n = 28,728) | ||||
---|---|---|---|---|---|---|
 |  | % | n |  | % | n |
Demographics | ||||||
Age (years), median (IQR) | 69 (50–87) |  | 1767 | 66 (45–80) |  | 28,728 |
Male gender, n (%) | 945 | 53.5 | 1765 | 14,776 | 51.5 | 28,714 |
Nursing home resident, n (%) | 109 | 6.2 | 1754 | 1698 | 6.0 | 28,347 |
Ethnicity, n (%) | ||||||
 European | 559 | 78.2 | 715 | 10,631 | 84.8 | 12,535 |
 North-African | 86 | 12.0 | 715 | 1173 | 9.4 | 12,535 |
 Sub-Saharan African | 35 | 4.9 | 715 | 322 | 2.6 | 12,535 |
 Asian | 29 | 4.1 | 715 | 301 | 2.4 | 12,535 |
 Hispanic | 6 | 0.8 | 715 | 108 | 0.9 | 12,535 |
Comorbidities | ||||||
Cardiovascular disease, n (%) | 622 | 35.3 | 1763 | 8208 | 28.6 | 28,663 |
History of arterial hypertension, n (%) | 597 | 33.9 | 1763 | 9529 | 33.2 | 28,663 |
Diabetes mellitus, n (%) | 394 | 22.3 | 1763 | 5530 | 19.3 | 28,663 |
Obesity, n (%) | 211 | 12.0 | 1763 | 3478 | 12.1 | 28,663 |
Chronic pulmonary disease, n (%) | 310 | 17.6 | 1763 | 3916 | 13.7 | 28,663 |
Chronic neurological disease, n (%) | 207 | 11.7 | 1763 | 2349 | 8.2 | 28,663 |
Chronic cognitive deficit, n (%) | 175 | 9.9 | 1763 | 2400 | 8.4 | 28,663 |
Chronic renal disease, n (%) | 332 | 18.8 | 1763 | 3363 | 13.4 | 28,663 |
Chronic liver disease, n (%) | 54 | 3.1 | 1763 | 774 | 2.7 | 28,663 |
Solid cancer, n (%) | 269 | 15.3 | 1763 | 2884 | 10.1 | 28,663 |
Haematological cancer, n (%) | 77 | 4.4 | 1763 | 529 | 2.1 | 28,663 |
Chronic Immunosuppression, n (%) | 147 | 8.3 | 1763 | 622 | 2.2 | 28,663 |
Socio-economic status | ||||||
Education level, n (%) | Â | Â | Â | Â | Â | Â |
 Lower | 249 | 25.8 | 965 | 3904 | 25.5 | 15,299 |
 Lower secondary | 290 | 30.1 | 965 | 4644 | 30.4 | 15,299 |
 Higher secondary | 270 | 28.0 | 965 | 4046 | 26.4 | 15,299 |
 Post-secondary higher education | 156 | 16.2 | 965 | 2705 | 17.7 | 15,299 |
Population densityb, median (IQR) | 1105 (419–2590) |  | 1738 | 740 (332–1778) |  | 25,916 |
Median taxable income per capitac, median (IQR) | 26,733 (23,807–28,756) |  | 1738 | 26,787 (23,807–28,352) |  | 25,916 |
Exposure | ||||||
Place of infection, n (%) | ||||||
 Community-acquired | 1430 | 81.6 | 1752 | 24,491 | 86.5 | 28,302 |
 Hospital-acquiredd | 231 | 13.2 | 1752 | 2302 | 8.1 | 28,302 |
 Nursing home-acquired | 91 | 5.2 | 1752 | 1509 | 5.3 | 28,302 |
Vaccination status | ||||||
Vaccination category, n (%) | ||||||
 Not vaccinated | 747 | 42.3 | 1767 | 15,010 | 52.2 | 28,728 |
 Partially vaccinated | 62 | 3.5 | 1767 | 1080 | 3.8 | 28,728 |
 Fully vaccinated | 497 | 28.1 | 1767 | 6779 | 23.6 | 28,728 |
 Fully vaccinated + booster | 461 | 26.1 | 1767 | 5859 | 20.4 | 28,728 |
Disease characteristics | ||||||
Fever at admission, n (%) | 376 | 50.9 | 738 | 6273 | 48.3 | 12,983 |
Viral syndrome at admission, n (%) | 322 | 43.3 | 744 | 5727 | 44.8 | 12,789 |
Lower respiratory symptoms at admission, n (%) | 520 | 68.6 | 758 | 8908 | 67.7 | 13,162 |
Upper respiratory symptoms at admission, n (%) | 69 | 9.6 | 716 | 1449 | 11.6 | 12,528 |
Anosmia at admission, n (%) | 56 | 8.0 | 703 | 1040 | 8.4 | 12,341 |
CRP (mg/l) on admission, median (IQR) | 95 (41–186) |  | 136 | 102 (47–168 |  | 1387 |
Hospital characteristics | ||||||
Type of hospital, n (%) | ||||||
 General hospital | 584 | 33.1 | 1767 | 21,417 | 74.6 | 28,728 |
 General hospital with university character | 700 | 39.6 | 1767 | 4982 | 17.3 | 28,728 |
 University hospital | 483 | 27.3 | 1767 | 2329 | 8.1 | 28,728 |
Mean ICU occupancy during hospital stay, median (IQR) | 19 (12–32) |  | 1767 | 27 (15–40) |  | 28,728 |
Outcomes | ||||||
Severe COVID-19e, n (%) | 440 | 25.2 | 1748 | 5840 | 20.7 | 28,147 |
ICU admission, n (%) | 298 | 16.9 | 1766 | 3325 | 11.6 | 28,722 |
ICU transfer, n (%) | Â | Â | Â | Â | Â | Â |
 General hospital | 81 | 27.2 | 298 | 2228 | 67.0 | 3325 |
 General hospital with university character | 126 | 42.3 | 298 | 677 | 20.4 | 3325 |
 University hospital | 91 | 30.5 | 298 | 420 | 12.6 | 3325 |
In-hospital mortality, n (%) | 230 | 13.2 | 1747 | 3309 | 11.8 | 28,131 |
Invasive ventilation, n (%) | 89 | 34.0 | 262 | 1089 | 42.5 | 2564 |
ECLS, n (%) | 7 | 2.7 | 262 | 85 | 3.4 | 2535 |
Hospital length of stay (days), median (IQR) | 9 (4–21) |  | 1767 | 7 (3–15) |  | 28,727 |