Table 1 Summary of the 14 pediatric cases of Exophiala dermatitidis infection reported in literature
No | Age | Gender | Clinical manifestation | Undelying disease | Susceptibility MIC (µg/mL) | Treatment | Outcome | References |
|---|---|---|---|---|---|---|---|---|
1 | 6 | F | Pneumonia | Cystic fibrosis | No data | ITCZ | Survive | [12] |
2 | 5 | M | Nosocomial intravascular infection | ALL | No data | ITCZ | Survive | [13] |
3 | 3 | M | Fungemia | ALL | No data | Catheter removal, AMB, 5-FC | Survive | [14] |
4 | 3 | M | Catheter-associated fungemia | HIV infection | No data | Catheter removal, AMB, ITCZ | Survive | [15] |
5 | 3 | M | Intracranial hypertension, paraplegia | None | No data | FLCZ, ITCZ, L-AMB | Death | [16] |
6 | 11 | F | Liver cirrhosis | None | AMB 1; ITCZ 0.064; VRCZ 0.016 | VRCZ | Death | [17] |
7 | 8 | M | Systemic lymphadenitis | None | No data | AMB, VRCZ | Death | [18] |
8 | 3 | M | Cerebritis | None | No data | AMB, ITCZ, 5-FC | Death | [19] |
9 | 8 | M | Brain abscess | None | No data | AMB, VRCZ, 5-FC | Death | [20] |
10 | 8 | M | Pneumonia | AML | No data | PSCZ | Death | [21] |
11 | 2 | F | Catheter-related bloodstream infection | Retroperitoneal teratoma | AMB 0.5; FLCZ 4; ITCZ 0.25; MCFG 2; VRCZ 0.12; 5-FC > 16 | Catheter removal, L-AMB | Survive | [22] |
12 | 4 | F | Lymphadenitis, hemiparesis | Inherited CARD9 deficiency | No data | L-AMB, VRCZ | Survive | [23] |
13 | 0.2 | F | Catheter-associated fungemia | Mitochondriopathy | AMB 1; CPFG 2; FLCZ 4; ITCZ ≤ 0.03; MCFG 2; PSCZ 0.06; VRCZ ≤ 0.03; 5-FC 4 | Catheter removal, FLCZ | Survive | [24] |
14 | 0.2 | M | Ecthyma gangrenosum, fungemia, pneumonia | MPAL | AMB 2; CPFG 0.25; FLCZ 8; ITCZ 0.25; MCFG 1; VRCZ 0.12; 5-FC 4 | CPFG, L-AMB, VRCZ, ELT, Surgery | Survive | Present case |