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Table 4 Pooled performance characteristics of the BCID2 for specific targets and sub-groups of targets of interest

From: Performance of BioFire Blood Culture Identification 2 Panel (BCID2) for the detection of bloodstream pathogens and their associated resistance markers: a systematic review and meta-analysis of diagnostic test accuracy studies

 

SE% (95% CI)

SP% (95% CI)

LR + (95% CI)

LR- (95% CI)

DOR (95% CI)

AUC (95% CI)

Studies included

I2

E. coli

98.1 (95.5–99.2)

99.5 (98.7–99.8)

179.15 (74.98–428.05)

0.02 (0.01–0.04)

9343.81 (2940/24–29,693.80)

0.990 (0.982–0.994)

9

0

Klebsiella spp.a

95.4 (89.6–98.0)

99.5 (98.7–99.8)

184.85 (72.68–470.13)

0.05 (0.02–0.10)

3979.15 (1227.25–12,901.71

0.984 (0.972–0.991)

9

0

Proteus spp.

85.0 (68.0–93.8)

99.6 (98.7–99.9)

232.04 (66.15–813.96)

0.15 (0.07–0.32)

1540.46 (358.89–6612.17)

0.975 (0.950–0.988)

7

0

Salmonella

85.0 (66.6–94.1)

99.7 (98.9–99.9)

289.25 (75.46–1108.74)

0.15 (0.07–0.33)

1917.95 (406.35–9052.75)

0.978 (0.953–0.990)

7

0

E. cloacae and S. marcescens

91.6 (79.6–96.8)

99.7 (98.9–99.9)

262.42 (79.55–865.68)

0.09 (0.04–0.20)

3101.8 (739.35–13,013.06)

0.982 (0.965–0.991)

8

6.6

A. baumannii complex

87.4 (69.0–95.6)

99.8 (99.0–99.9)

350.49 (84.19–1459.07)

0.13 (0.05–0.29)

2780.81 (529.13–14,614.38)

0.981 (0.958–0.992)

5

0

P. aeruginosa

92.7 (83.1–97.0)

99.6 (98.8–99.9)

215.16 (73.83–627.00)

0.07 (0.04–0.20)

2930.15 (795.44–10,793.74)

0.982 (0.966–0.990)

9

0

S. maltophilia

86.1 (63.0–95.8)

99.8 (99.0–1.00)

454.15 (86.29–2390.39)

0.14 (0.05–0.36)

3270.71 (484.31–22,088.03)

0.983 (0.957–0.993)

4

0

B. fragilis

87.2 (70.4–95.1)

99.5 (98.2–99.9)

173.12 (47.72–628.13)

0.13 (0.06–0.29)

1340.50 (292.22–6149.32)

0.973 (0.945–0.987)

6

0

H. influenzae

78.7 (39.9–95.3)

99.8 (98.1–1.00)

462.98 (41.17–5206.10)

0.21 (0.06–0.72)

2167.39 (144.62–32,481.75)

0.979 (0.923–0.994)

3

31.9

N. meningitidis

73.1 (39.1–92.0)

99.8 (98.1–1.00)

327.67 (38.27–2805.62)

0.27 (0.10–0.75)

1213.69 (112.58–13,083.73)

0.972 (0.914–0.991)

3

0

E. faecalis

92.3 (83.5–96.6)

99.6 (98.9–99.8)

225.77 (83.73–608.76)

0.08 (0.04–0.15)

2938.91 (881.60–9797.14)

0.982 (0.967–0.990)

9

0

E. faecium

92.3 (81.9–97.0)

99.6 (98.7–99.9)

216.44 (70.69–662.76)

0.08 (0.04–0.17)

2816.75 (722.86–10,975.99)

0.982 (0.964–0.991)

7

0

L. monocytogenes

86.1 (55.7–96.8)

99.9 (98.9–1.00)

577.99 (73.61–4538.35)

0.14 (0.04–0.44)

4157.81 (393.01–43,987.07)

0.985 (0.952–0.995)

3

0

Staphylococcus spp.

97.4 (94.1–98.8)

98.8 (97.3–99.5)

83.35 (36.93–188.14)

0.03 (0.13–0.06)

3133.31 (1044.73–9397.36)

0.982 (0.970–0.990)

9

17.4

S. epidermidis

92.0 (77.4–97.5)

98.1 (93.1–99.5)

48.79 (13.35–178.29)

0.08 (0.03–0.23)

600.80 (113.95–3167.703)

0.961 (0.914–0.983)

8

52.7

S. lugdunensis

87.7 (66.1–96.3)

99.6 (98.0–99.9)

211.065 (42.892–1038.63)

0.12 (0.05–0.34)

1708.12 (260.86–11,184.63)

0.976 (0.942–0.991)

4

0

Candida spp.b

92.0 (81.5–96.8)

99.5 (98.6–99.8)

199.18 (66.57–595.94)

0.08 (0.04–0.17)

2474.911 (653.62–9371.24)

0.980 (0.962–0.990)

8

0

mcr-1

77.3 (42.6–94.0)

99.6 (96.4–1.00)

183.42 (21.61–1556.53)

0.23 (0.07–0.71)

804.36 (71.33–9071.12)

0.966 (0.894 to0.990)

3

0

mecA/C

93.8 (88.6–96.7)

98.8 (97.6–99.4)

78.94 (38.88–160.24)

0.06 (0.04–0.11)

1262.31 (510.55–3121.01)

0.973 (0.958–0.982)

8

0

vanA/B

90.9 (76.7–96.8)

99.7 (99.0–99.9)

347.03 (92.35–1304.12)

0.09 (0.04–0.21)

3820.95 (793.29–18,403.99)

0.984 (0.966–0.993)

5

0

  1. SE = Sensitivity; SP = Specificity; LR = Likelihood Ratio; DOR = Diagnostic Odds Ratio; AUC = Area Under the Curve. aIncluding K. aerogenes, K. oxytoca and K. pneumoniae group; bIncluding C. albicans, C. auris, C. glabrata, C. cruzei, C. parapsilosis, C. tropicalis