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Table 3 Summary of findings for diagnostic accuracy of Luminex NxTAG RPP™ for the diagnosis of influenza A virus

From: Diagnostic accuracy of multiplex respiratory pathogen panels for influenza or respiratory syncytial virus infections: systematic review and meta-analysis

Outcome

Effect per 1000 patients tested

№ of studies

(№ of samples)

Test accuracy

certainty of evidence

Pre-test probability of 5%

Pre-test probability of 20%

Index and comparator tests positive (I + /C +) (patients with influenza A infection)

49 (45 to 50)

194 (178 to 200)

9 studies

460 samples

      a

LOW

Index test negative, comparator positive (I−/C +) (patients incorrectly classified as not having influenza A infection)

1 (0 to 5)

6 (0 to 22)

 

Index and comparator tests negative (I−/C−) (patients without influenza A infection)

950 (941 to 950)

800 (792 to 800)

9 studies

3677 samples

      a

LOW

Index test positive, comparator negative (I + /C−) (patients incorrectly classified as having influenza A infection)

0 (0 to 9)

0 (0 to 8)

 
  1. C comparator, CrI credible interval, I index test, RPP respiratory pathogen panel
  2. Patient or population: adults and children with symptoms of acute lower respiratory infection
  3. Setting: worldwide
  4. Index test: Luminex NxTAG RPP™
  5. Comparator tests: other RPP
  6. Predicted sensitivity: 0.97 (95% CrI: 0.89 to 1.00) | Predicted specificity: 1.00 (95% CrI: 0.99 to 1.00)
  7. aDowngraded two levels for risk of bias: there is high or unclear risk of bias on the patient selection and flow and timing domains for all included studies. Six studies were planned after the test was performed on patients selected by physician (e.g. respiratory symptoms) with no clear inclusion and exclusion criteria, which is at high risk of introducing bias for evaluating diagnostic test accuracy