Diagnostic accuracy of multiplex respiratory pathogen panels for influenza or respiratory syncytial virus infections: systematic review and meta-analysis

Table 1 Summary of characteristics of the studies included in this review

Study ID	Setting	Participants	Samples	n	Comparator tests
Beckmann 2016	Switzerland	Children and adults Symptoms and fever not reported	NPS (199), BAL (76), others (7)	282	RespiFinder-221^a
Brotons 2016	Spain	< 18 years with ALRI Fever not reported	NPA	320	Anyplex II RV16 assay^a,b,c
Chan 2017	China	Children and adults with ARI Fever not reported	NPA	133	RT-PCR AND DFA^a
Chen 2016	China	Patients with ARI Fever not reported	NPS	284	FilmArray RP^a,d,e
Esposito 2016	Italy	Children with ARI in PICU and children with pneumonia by M. pneumoniae	NPS	185	xTAG RVP FAST v2^a,c RT-PCR
Gonsalves 2019	USA, Canada	Children and adults with ARI Fever not reported	NPW	2132	xTAG RVP^a,c OR bidirectional sequencing
Lee 2017	Singapore	Not reported	Respiratory samples	142	xTAG RVP FAST v2^a,c
Locher 2019	Canada	Adults, mostly immunocompromised and with underlying chronic lung conditions, with ARI	Bronchoscopy collected samples	133	FilmArray RP^a,d,e
Sails 2017	United Kingdom	“Symptomatic” Other characteristics not reported	NPS (122), throat swabs (53), endotracheal (47), BAL (17), others (122)	314	In-house multiplex RT-PCR panel
Tang 2016	USA	Patients with respiratory symptoms Fever not reported	NPS	404	FilmArray RP^a,d,e

ALRI acute lower respiratory infection, ARI acute respiratory infection, BAL broncho-alveolar lavage, DFA direct immunofluorescence, n sample size, NPA nasopharyngeal aspirate, NPS nasopharyngeal swabs, RP respiratory panel; RVP respiratory virus panel
^aComplies with CE-IVD regulations
^bComplies with Canadian Department of Health regulations
^cComplies with Korea Food and Drug Administration regulations
^dComplies with the United States Food and Drug Administration regulations
^eComplies with Therapeutic Goods Administration regulations

ISSN: 1471-2334