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Table 2 A: Changes in patients laboratory value:

From: Comparison of the safety and immunogenicity of the BNT-162b2 vaccine and the ChAdOx1 vaccine for solid organ transplant recipients: a prospective study

Overall

 

Screening

Before 2nd dose

After 2nd dose

Parameter

Mean (SE)

Mean (SE)

P-value

Mean (SE)

P-value

HB

137.26 (0.96)

135.56 (1.56)

0.712

138.28 (1.93)

0.772

Platelet

242.04 (3.78)

238.71 (6.43)

0.349

227.92 (7.51)

0.90

INR

1.05 (0.01)

1.07 (0.02)

0.083

1.03 (0.01)

0.0425

Serum Creatinine

102.59 (2.79)

103.54 (4.57)

0.251

106.41 (7.12)

0.618

ALT

21.6 (0.68)

23.34 (1.13)

0.237

23.36 (3.3)

0.768

AST

19.3 (0.36)

21.04 (0.96)

0.611

18.87 (1.03)

0.889

ALK

98.56 (2.74)

109.92 (5.29)

0.722

94.62 (4.29)

0.817

GGT

57.27 (4.79)

74.17 (9.62)

0.918

62.03 (9.75)

0.436

Bilirubin total

10.17 (0.59)

10.39 (1.33)

0.734

9.09 (0.47)

0.083

Tacrolimus level

6.17 (0.16)

6.31 (0.31)

0.842

6.1 (0.36)

0.812

Pfizer

 HB

137.23 (1.2)

135.56 (1.82)

0.980

136.98 (2.22)

0.517

 Platelet

235.24 (4.61)

236.95 (7.45)

0.709

224.96 (8.61)

0.69

 INR

1.04 (0.01)

1.06 (0.02)

0.033

1.03 (0.01)

0.08

 Serum creatinine

102.82 (3.79)

103.71 (6.03)

0.527

108.57 (8.34)

0.477

 ALT

21.6 (0.83)

23.18 (1.34)

0.409

23.51 (3.91)

0.763

 AST

19.49 (0.43)

21.13 (1.1)

0.541

18.89 (1.21)

0.844

 ALK

100.59 (3.58)

113.85 (6.72)

0.727

92.95 (4.58)

0.778

 GGT

62.7 (6.14)

75.36 (10.86)

0.972

56.22 (8.82)

0.138

 Bilirubin total

10.71 (0.81)

11.04 (1.77)

0.647

9.33 (0.54)

0.047

 Tacrolimus level

6.07 (0.19)

5.82 (0.32)

0.139

6.09 (0.38)

0.858

AstraZeneca

 HB

137.31 (1.62)

135.58 (3.08)

0.4106

143.73 (3.51)

0.629

 Platelet

254.98 (6.46)

243.87 (12.84)

0.231

241.05 (14.49)

0.22

 INR

1.1 (0.04)

1.12 (0.09)

0.455

1.03 (0.04)

0.1723

 Serum creatinine

102.14 (3.69)

103.06 (4.23)

0.228

96 (10.02)

0.7632

 ALT

21.59 (1.18)

23.84 (2.06)

0.365

22.7 (4.2)

0.986

 AST

18.93 (0.64)

20.78 (1.96)

0.968

18.8 (1.55)

0.784

 ALK

94.69 (4.13)

98.64 (6.69)

0.943

102.3 (11.72)

0.909

 GGT

44.44 (6.8)

68.7 (20.7)

0.73

97.56 (43.91)

0.236

 Bilirubin total

9.16 (0.75)

8.5 (0.65)

0.611

7.98 (0.85)

0.315

 Tacrolimus level

6.35 (0.26)

7.63 (0.71)

0.032

6.12 (1.12)

0.8714

B: After propensity score matching

Overall (n = 296)

 

Screening

Before 2nd dose

After 2nd dose

Parameter

Mean (SE)

Mean (SE)

P-value

Mean (SE)

P-value

HB

137.19 (1.17)

136.39 (2.05)

0.750

139.9 (2.55)

0.311

Platelet

248.62 (4.67)

246.83 (9.2)

0.345

240.13 (10.59)

0.124

INR

1.07 (0.02)

1.05 (0.04)

0.868

1.03 (0.02)

0.055

Serum Creatinine

103.69 (2.94)

103.2 (3.72)

0.167

98.16 (4.26)

0.525

ALT

20.84 (0.81)

21.7 (1.21)

0.104

20.13 (1.83)

0.140

AST

18.63 (0.42)

19.7 (0.96)

0.877

18.16 (0.91)

0.115

ALK

96.57 (3.07)

105.28 (6.39)

0.280

100.69 (6.94)

0.420

GGT

51.92 (5.78)

78.15 (15.36)

0.993

86.65 (20.66)

0.6311

Bilirubin total

9.53 (0.52)

9.45 (0.56)

0.501

9.39 (0.66)

0.350

Tacrolimus level

6.35 (0.18)

6.67 (0.42)

0.286

6.11 (0.42)

0.9926

Pfizer

HB

137.06 (1.68)

137.02 (2.76)

0.932

137.68 (3.47)

0.370

Platelet

242.18 (6.73)

249.12 (13.04)

0.778

239.64 (14.43)

0.296

INR

1.04 (0.01)

1.01 (0.02)

0.663

1.03 (0.02)

0.197

Serum Creatinine

105.23 (4.58)

103.3 (5.77)

0.401

99.21 (4.16)

0.33

ALT

20.09 (1.11)

20.12 (1.43)

0.162

18.82 (1.76)

0.057

AST

18.33 (0.54)

18.9 (0.85)

0.765

17.84 (1.14)

0.021

ALK

98.46 (4.56)

110.32 (10.02)

0.252

99.87 (8.72)

0.273

GGT

59.79 (9.43)

85.15 (22.14)

0.911

79.64 (20.34)

0.339

Bilirubin total

9.91 (0.73)

10.17 (0.85)

0.612

10.09 (0.89)

0.90

Tacrolimus level

6.36 (0.26)

5.91 (0.46)

0.389

6.11 (0.38)

0.888

AstraZeneca

 HB

137.31 (1.62)

135.58 (3.08)

0.4106

143.73 (3.51)

0.629

 Platelet

254.98 (6.46)

243.87 (12.84)

0.231

241.05 (14.49)

0.22

 INR

1.1 (0.04)

1.12 (0.09)

0.455

1.03 (0.04)

0.1723

 Serum creatinine

102.14 (3.69)

103.06 (4.23)

0.228

96 (10.02)

0.7632

 ALT

21.59 (1.18)

23.84 (2.06)

0.365

22.7 (4.2)

0.986

 AST

18.93 (0.64)

20.78 (1.96)

0.968

18.8 (1.55)

0.784

 ALK

94.69 (4.13)

98.64 (6.69)

0.943

102.3 (11.72)

0.909

 GGT

44.44 (6.8)

68.7 (20.7)

0.73

97.56 (43.91)

0.236

 Bilirubin total

9.16 (0.75)

8.5 (0.65)

0.611

7.98 (0.85)

0.315

 Tacrolimus level

6.35 (0.26)

7.63 (0.71)

0.032

6.12 (1.12)

0.8714