Healthy individuals (n = 192) | Patients with severe infection (n = 167) | p-value | |
---|---|---|---|
Age (years) | 44 (33–52) | 63 (38–75) | < 0.001 |
Gender (n, %) | |||
Male | 81 (42) | 76 (46) | 0.594 |
Female | 111 (58) | 91 (54) | |
BMI (kg/m2) | 26.2 (23.3–28.7) | 24.6 (21.5–27.1) | < 0.001 |
Comorbidities | |||
Hypertension | 20 (10) | 84 (50) | < 0.001 |
Cardiovascular disease | 16 (8) | 91 (54) | < 0.001 |
Diabetes mellitus | 3 (2) | 30 (18) | < 0.001 |
Renal disease | 5 (3) | 23 (14) | 0.001 |
Malignancy | 1 (0.5) | 16 (10) | < 0.001 |
Type of infection (n, %) | |||
CAP | NA | 46 (28) | NA |
VAP | 1 (0.6) | ||
Pyelonephritis | 44 (26) | ||
Abdominal infection | 6 (4) | ||
Primary bacteremia | 2 (1) | ||
Other | 93 (56) | ||
Clinical and laboratory parameters | |||
Temperature (°C) | NA | 38.4 (38.2–38.5) | |
Mean arterial pressure (mmHg) | 110 (92–120) | NA | |
Heart rate (bpm) | 100 (92–110) | ||
Respiratory rate (bpm) | 19 (17–22) | ||
Creatinine (µ/L) | 83 (65–116) | ||
Leukocyte count (× 109) | 15.0 (12.8–19.3) | ||
Lymphocytes (× 109) | 1.5 (0.9–2.2) | ||
28-day mortality (n, %) | 0 (0) | 3 (1.8) | 0.099 |