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Table 1 Patient characteristics

From: Characterization of sepsis inflammatory endotypes using circulatory proteins in patients with severe infection: a prospective cohort study

 

Healthy individuals (n = 192)

Patients with severe infection (n = 167)

p-value

Age (years)

44 (33–52)

63 (38–75)

< 0.001

Gender (n, %)

 Male

81 (42)

76 (46)

0.594

 Female

111 (58)

91 (54)

BMI (kg/m2)

26.2 (23.3–28.7)

24.6 (21.5–27.1)

< 0.001

Comorbidities

 Hypertension

20 (10)

84 (50)

< 0.001

 Cardiovascular disease

16 (8)

91 (54)

< 0.001

 Diabetes mellitus

3 (2)

30 (18)

< 0.001

 Renal disease

5 (3)

23 (14)

0.001

 Malignancy

1 (0.5)

16 (10)

< 0.001

Type of infection (n, %)

 CAP

NA

46 (28)

NA

 VAP

 

1 (0.6)

 

 Pyelonephritis

 

44 (26)

 

 Abdominal infection

 

6 (4)

 

 Primary bacteremia

 

2 (1)

 

 Other

 

93 (56)

 

Clinical and laboratory parameters

 Temperature (°C)

NA

38.4 (38.2–38.5)

 

 Mean arterial pressure (mmHg)

 

110 (92–120)

NA

 Heart rate (bpm)

 

100 (92–110)

 

 Respiratory rate (bpm)

 

19 (17–22)

 

 Creatinine (µ/L)

 

83 (65–116)

 

 Leukocyte count (× 109)

 

15.0 (12.8–19.3)

 

 Lymphocytes (× 109)

 

1.5 (0.9–2.2)

 

28-day mortality (n, %)

0 (0)

3 (1.8)

0.099

  1. Bold values indicate significant p-values < 0.05
  2. Data are presented as median (IQR) or n (%).BMI body mass index, CAP community acquired pneumonia, VAP ventilator-associated pneumonia, NA not applicable