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Table 1 Baseline characteristics on admission to the hospital of patients with low MxA, intermediate MxA and high MxA

From: Association of human myxovirus resistance protein A with severity of COVID-19

 

Low MxA < 400 μg/L (N = 36)

Intermediate MxA 400–799 μg/L (N = 73)

High MxA ≥ 800 μg/L (N = 159)

p-value

Female gender, n/N (%)

18/36 (50%)

31/73 (43%)

66/159 (42%)

0.647^

Age (years)

61

58

58

0.874#

Q1–Q3

48–71

44–69

48–69

 

BMI (kg/m2)

27.1

30.1

29.9

0.237#

Q1–Q3

24.0–31.8

26.1–34.6

27.0–34.5

 

Smoking status, n/N (%)

   

0.306^

Non-smoker

16/26 (62%)

39/64 (61%)

71/133 (53%)

 

Ex-smoker

7/26 (27%)

20/64 (31%)

56/133 (42%)

 

Smoker

3/26 (12%)

5/64 (8%)

6/133 (5%)

 

Vaccination for COVID-19

   

0.563^

Unvaccinated

36/36 (100%)

71/73 (97%)

154/159 (97%)

 

Partially vaccinated

0/36 (0%)

2/73 (3%)

5/159 (3%)

 

SARS-CoV-2-specific IgG (%), n/N (%)

24/30 (80%)

30/61 (49%)

61/138 (44%)

0.002^

Native SpO2 (%)

96

95

94

 < 0.001#

Q1–Q3

95–98

92–96

89–96

 

Temperature (°C)

37.5

37.9

38.2

0.012#

Q1–Q3

37.2–38.4

37.4–38.5

37.6–38.7

 

Blood lymphocytes (× 109/L)

1.23

0.99

1.05

0.583#

Q1–Q3

0.70–1.53

0.72–1.21

0.71–1.31

 

CRP (mg/L)

40

48

64

0.128#

Q1–Q3

14–109

17–107

36–106

 

PCT (μg/L)

0.09

0.12

0.14

0.017#

Q1–Q3

0.05–0.19

0.65–0.24

0.07–0.32

 

Interleukin-6 (ng/L)

11.3

18.7

36.9

 < 0.001#

Q1–Q3

3.9–55.4

7.2–54.1

15.7–80.3

 

Ferritin (μg/L)

573

678

629

0.354#

Q1–Q3

243–838

257–1225

337–1037

 

Pre-existent comorbidities, n/N (%)

    

 Obesity

13/29 (45%)

29/58 (50%)

73/147 (50%)

0.883^

 Hypertension

11/36 (31%)

27/73 (37%)

59/159 (37%)

0.751^

 Diabetes Mellitus

6/36 (17%)

15/73 (21%)

43/159 (27%)

0.309^

 Obstructive Sleep Apnea

5/36 (14%)

9/73 (12%)

28/159 (18%)

0.561^

 Asthma

5/36 (14%)

8/73 (11%)

19/159 (12%)

0.906^

 COPD

0/36 (0%)

4/73 (6%)

11/159 (7%)

0.264^

Home medication, n/N (%)

    

 Immunosuppressive

2/36 (6%)

2/73 (3%)

18/156 (12%)

0.065^

 Biological

1/35 (3%)

2/73 (3%)

2/156 (1%)

0.680^

 Cytostatic

0/35 (0%)

0/73 (0%)

2/156 (1%)

0.498^

  1. #Jonckheere-Terpstra test; ^Pearson's chi-squared test
  2. Values are medians for continuous variables and percentages for frequencies
  3. BMI body mass index, IgG immunoglobulin G, CRP C-reactive protein, PCT procalcitonin, COPD chronic obstructive pulmonary disease, MxA human myxovirus resistance protein A, Q1 lower quartile (25th percentile), Q3 upper quartile (75th percentile), SpO2 oxygen saturation on admission on ambient air