Characteristics | 28-day survivors (n = 6) | 28-day non-survivors (n = 10) | P-value |
---|---|---|---|
Age (years) | 60.2 ± 10.0 | 74.7 ± 12.9 | 0.04 |
Men, n (%) | 4 (66.7) | 10 (100.0) | 0.13 |
Mechanical ventilation, n (%) | 3 (50.0) | 10 (100.0) | 0.04 |
Use of vasoactive drugs, n (%) | 4 (66.7) | 10 (100.0) | 0.13 |
Immunosuppression, n (%) | 2 (33.3) | 1 (10.0) | 0.52 |
Combination antibiotic therapy, n (%) | 6 (100.0) | 8 (80.0) | 0.50 |
Multidrug-resistant pathogens, n (%) | 2 (33.3) | 6 (60.0) | 0.61 |
Polymicrobial BSIs, n (%) | 1 (16.7) | 5 (50.0) | 0.31 |
DNA load in the first ddPCR (copies/mL), median (IQR) | 247.0 (37.8, 1375.0) | 191.0 (47.5, 2428.5) | 0.79 |
DNA load in the second ddPCR (copies/mL), median (IQR) | 0.0 (0.0, 106.8) | 986.0 (248.0 2423.0) | < 0.01 |
DNA load in the third ddPCR (copies/mL), median (IQR) | 0.0 | 3000.0 (812.0, 8426.0) | < 0.01 |
Laboratory investigation on the first day | Â | Â | Â |
White blood cells, median (IQR) ×109/L | 11.0 (2.9, 39.4) | 12.1 (4.9, 15.3) | 0.88 |
Platelets, median (IQR) ×109/L | 91.0 (44.0, 131.7) | 63.0 (38.5, 164.5) | 0.90 |
 C-reactive protein (mg/L), median (IQR) | 87.9 (64.6, 191.1) | 130.0 (70.7, 241.1) | 0.37 |
Procalcitonin (ng/mL), median (IQR) | 2.1 (0.7, 96.6) | 5.6 (1.4, 31.0) | 0.88 |
Laboratory investigation on the 2nd − 4th day |  |  |  |
White blood cells, median (IQR) ×109/L | 10.7 (3.1, 15.1) | 8.9 (6.2, 10.8) | 0.28 |
Platelets, median (IQR) ×109/L | 83.5 (35.3, 120.8) | 32.5 (24.8, 82.5) | 0.57 |
 C-reactive protein (mg/L), median (IQR) | 64.0 (45.9, 150.1) | 185.0 (138.9, 237.2) | 0.49 |
Procalcitonin (ng/mL), median (IQR) | 1.3 (0.2,19.1) | 19.7 (3.4, 46.0) | 0.66 |
Laboratory investigation on the 5th − 7th day |  |  |  |
White blood cells, median (IQR) ×109/L | 10.4 (6.0, 13.9) | 12.4 (4.0, 12.7) | 0.38 |
Platelets, median (IQR) ×109/L | 100.0 (30.3, 165.0) | 59.0 (4.5, 79.5) | 0.67 |
 C-reactive protein (mg/L), median (IQR) | 45.7 (22.5, 85.1) | 217.3 (176.2, 247.4) | 0.18 |
Procalcitonin (ng/mL), median (IQR) | 3.26 (0.27,7.52) | 12.8 (4.0, 48.1) | 0.26 |
APACHE II score | 26.5 ± 9.6 | 27.1 ± 4.6 | 0.89 |
SOFA score | 11.3 ± 4.4 | 10.8 ± 2.1 | 0.79 |