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Table 1 Characteristics of the patients with BSIs

From: Pathogen load and species monitored by droplet digital PCR in patients with bloodstream infections: A prospective case series study

Characteristics

28-day survivors (n = 6)

28-day non-survivors (n = 10)

P-value

Age (years)

60.2 ± 10.0

74.7 ± 12.9

0.04

Men, n (%)

4 (66.7)

10 (100.0)

0.13

Mechanical ventilation, n (%)

3 (50.0)

10 (100.0)

0.04

Use of vasoactive drugs, n (%)

4 (66.7)

10 (100.0)

0.13

Immunosuppression, n (%)

2 (33.3)

1 (10.0)

0.52

Combination antibiotic therapy, n (%)

6 (100.0)

8 (80.0)

0.50

Multidrug-resistant pathogens, n (%)

2 (33.3)

6 (60.0)

0.61

Polymicrobial BSIs, n (%)

1 (16.7)

5 (50.0)

0.31

DNA load in the first ddPCR (copies/mL), median (IQR)

247.0 (37.8, 1375.0)

191.0 (47.5, 2428.5)

0.79

DNA load in the second ddPCR (copies/mL), median (IQR)

0.0 (0.0, 106.8)

986.0 (248.0 2423.0)

< 0.01

DNA load in the third ddPCR (copies/mL), median (IQR)

0.0

3000.0 (812.0, 8426.0)

< 0.01

Laboratory investigation on the first day

   

White blood cells, median (IQR) ×109/L

11.0 (2.9, 39.4)

12.1 (4.9, 15.3)

0.88

Platelets, median (IQR) ×109/L

91.0 (44.0, 131.7)

63.0 (38.5, 164.5)

0.90

 C-reactive protein (mg/L), median (IQR)

87.9 (64.6, 191.1)

130.0 (70.7, 241.1)

0.37

Procalcitonin (ng/mL), median (IQR)

2.1 (0.7, 96.6)

5.6 (1.4, 31.0)

0.88

Laboratory investigation on the 2nd − 4th day

   

White blood cells, median (IQR) ×109/L

10.7 (3.1, 15.1)

8.9 (6.2, 10.8)

0.28

Platelets, median (IQR) ×109/L

83.5 (35.3, 120.8)

32.5 (24.8, 82.5)

0.57

 C-reactive protein (mg/L), median (IQR)

64.0 (45.9, 150.1)

185.0 (138.9, 237.2)

0.49

Procalcitonin (ng/mL), median (IQR)

1.3 (0.2,19.1)

19.7 (3.4, 46.0)

0.66

Laboratory investigation on the 5th − 7th day

   

White blood cells, median (IQR) ×109/L

10.4 (6.0, 13.9)

12.4 (4.0, 12.7)

0.38

Platelets, median (IQR) ×109/L

100.0 (30.3, 165.0)

59.0 (4.5, 79.5)

0.67

 C-reactive protein (mg/L), median (IQR)

45.7 (22.5, 85.1)

217.3 (176.2, 247.4)

0.18

Procalcitonin (ng/mL), median (IQR)

3.26 (0.27,7.52)

12.8 (4.0, 48.1)

0.26

APACHE II score

26.5 ± 9.6

27.1 ± 4.6

0.89

SOFA score

11.3 ± 4.4

10.8 ± 2.1

0.79

  1. IQR, interquartile range; APACHE II: Acute Physiology and Chronic Health Evaluation II; SOFA: Sequential Organ Failure Assessment; ddPCR, droplet digital PCR; Values are presented as the mean ± SD, median (IQR), or number of subjects (percentage of the column total). Pathogen DNA loads on the third ddPCR assay were detected in 6 survivors and 5 non-survivors, respectively. aThe DNA load of blood culture positive pathogens by ddPCR assay