Fig. 1
SARS-CoV-2 Vaccination response correlates with CD19 cell count at vaccination, and with the interval size between Rituximab treatment and vaccination. A Scatter plot showing correlation between CD19 counts and anti- SARS-CoV-2-S1 IgGs. A linear regression model was fitted to the data. B Scatter plot showing correlation between days between Rituximab to 1st vaccination and anti-SARS-CoV-2-S1 IgGs. C Scatter plot showing correlation between days between Rituximab to 1st vaccination and CD19 counts. In (B), and (C), a generalized additive regression model was fitted to the data. In A-C, patients with positive humoral response are plotted in red, patients without humoral response are plotted in black. Black dashed lines indicate regression models fitted to the data. Grey areas indicate 95% confidence interval of the regression models. Dashed red lines indicate the cutoff for positive humoral response (≥ 21.8 BAU/ml), CD19 counts (> 21/µl), and days from anti-CD19-treatment to 1st vaccination (> 197), above which humoral response was recorded for all patients, respectively