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Table 2 Comparison of laboratory indexes between children and adults

From: Different clinical features of children and adults in regional outbreak of Delta COVID-19

Indicators

Children (80)

Adults (132)

*P value

WBC (109/L)

4.96 (2.14–22.59)

5.47 (1.17-11.00)

0.5562

Decreased WBC (N)

29/80

40/131

0.4500

Lymphocytes (109/L)

1.98 (0.25–4.25)

1.20 (0.29–4.27)

< 0.0001

Decreased lymphocytes (N)

24/80

57/131

0.0584

Interleukin-6 (0–7 pg/mL)

5.87 (1.50–61.40)

15.15 (1.79–166.30)

< 0.0001

Elevated interleukin-6 (n)

32/78

93/131

< 0.0001

Albumin (> 40 g/L)

45.64 ± 3.14

43.31 ± 3.26

< 0.0001

Decreased albumin (N)

1/79

14/113

0.0048

Total bilirubin (5.1–19.0 µmol/L)

4.7 (1.2–12.1)

7.1 (2.2–17.7)

< 0.0001

Elevated total bilirubin (N)

0/79

0/113

> 0.9999

ALT (< 40 U/L)

11.5 (4.6–478.0)

27.2 (4.0–275.0)

< 0.0001

Elevated ALT (N)

4/79

42/113

< 0.0001

AST (< 40 U/L)

25.3 (12.0–228.0)

27.3 (8.8–221.0)

0.3576

Elevated AST (N)

6/79

36/112

< 0.0001

Creatinine (µmol/L)

42.0 (28.0–73.0)

57.0 (32.0–94.0)

< 0.0001

Elevated creatinine (n)

2/79

1/111

0.5714

Proteinuria (N)

22/75

45/112

0.1615

Viral-load (ORF1ab, CT)

19.80 (5.99–36.58)

21.01 (7.05–41.00)

0.1910

Viral-load (N, CT)

19.33 (5.66–41.00)

20.48 (5.80–41.00)

0.5440

  1. Lymphocytes, normal range: 2–6 years old, 1.8–6.3 × 109/L; 6–13 years old, 1.5–4.6 × 109/L; adults, 1.2–3.8 × 109/L; Creatinine (reference intervals, µmol/L): for child, 28 days to < 2 years old, 13–33; 2 to < 6 years old, 19–44; 6 to < 13 years old, 27–66; 13 to < 15 years old, male 37–93, female 33–75, according to Reference intervals of clinical biochemistry tests commonly used for children (WS/T 780–2021); for adult, male 20–59 years old, 57–97, 60–79 years old, 57–111; female 20–59 years old, 41–73, 60–79 years old, 41–81, according to Reference intervals for common clinical biochemistry tests (WS/T 404.4–2018)
  2. N: The number of people. Because the number of critical cases is small, it is not included in the comparison of laboratory indexes; P value: Comparison of mild and moderate cases in children or adults
  3. WBC white blood cells, normal range: 2–6 years old, 4.4–11.9 × 109/L; 6–13 years old, 4.3–11.3 × 109/L; adult, 4.1–10 × 109/L; ALT alanine aminotransferase; AST aspartate transferase; CT cycle threshold (the number of cycles experienced when the fluorescence signal in each reaction tube reaches the set threshold value
  4. *P value: comparison between children and adults