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Table 3 Results from models with baseline mSOFA and delta mSOFA score

From: A modified Sequential Organ Failure Assessment score for dengue: development, evaluation and proposal for use in clinical trials

 

Est

Baseline mSOFA score

Delta mSOFA score

Est (95% CI)

p

Scaled Brier score (95% CI)

AUC (95% CI)

Est (95% CI)

p

Scaled Brier score (95% CI)

AUC (95% CI)

ICU admission

OR

1.66 (1.30; 2.23)

 < 0.001

0.20 (0.06; 0.39)

0.71 (0.59; 0.83)

1.55 (1.21; 2.10)

0.002

0.16 (0.03; 0.31)

0.66 (0.53; 0.78)

ICU discharge

HR

0.64 (0.52; 0.78)

 < 0.001

–

–

0.68 (0.56; 0.84)

 < 0.001

–

–

Hospital discharge

HR

0.66 (0.59; 0.75)

 < 0.001

–

–

0.84 (0.77; 0.91)

 < 0.001

–

–

Stop IV fluid use

HR

0.82 (0.75; 0.90)

 < 0.001

–

–

0.76 (0.69; 0.84)

 < 0.001

–

–

Total volume of IV fluid use

MR

1.18 (1.12; 1.25)

 < 0.001

–

–

1.19 (1.14; 1.25)

 < 0.001

–

–

Mechanical ventilation

OR

3.66 (2.09; 8.49)

 < 0.001

0.56 (0.29; 0.97)

0.92 (0.75; 1.00)

3.64 (1.92; 9.84)

0.002

0.52 (0.23; 0.91)

0.93 (0.81; 1.00)

Vasopressor support

OR

3.73 (2.08; 9.17)

 < 0.001

0.51 (0.18; 0.86)

0.96 (0.91; 1.00)

1.95 (1.40; 3.16)

 < 0.001

0.45 (0.02; 0.97)

0.76 (0.47; 1.00)

Haemofiltration

OR

6.24 (2.48; 39.9)

0.005

0.78 (0.33; 0.98)

0.99 (0.96; 1.00)

4.90 (1.98; 137)

 < 0.001

0.75 (0.63; 0.99)

1.00 (0.99; 1.00)

Mortality

OR

4.60 (2.12; 22.8)

0.006

0.74 (0.19; 0.97)

0.98 (0.95; 1.00)

3.75 (1.86; 38.4)

 < 0.001

1.00 (0.88; 1.00)

1.00 (1.00; 1.00)

  1. All parameters are estimated from models with only one predictor ‘baseline mSOFA score’ or ‘delta mSOFA score’ with a linear effect. Logistic regression model is used for binary endpoints (ICU admission, mechanical ventilation, vasopressor support, haemofiltration, and death), Cox proportional hazard model is used for time-to-event endpoints (ICU discharge, hospital discharge, and stop IV fluid use), and linear regression model is used for total volume of IV fluid use with log-transformation. The estimates (OR, HR, or MR) and 95% CIs are reported for each point increase of baseline mSOFA or delta mSOFA score
  2. AUC area under the curve; CI confidence interval; Est estimate; HR hazard ratio; ICU intensive care unit; IV intravenous fluid; MR mean ratio; OR odds ratio
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BMC Infectious Diseases

ISSN: 1471-2334

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