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Table 1 Modified SOFA score for dengue

From: A modified Sequential Organ Failure Assessment score for dengue: development, evaluation and proposal for use in clinical trials

System

Score

0

1

2

3

4

Respiratory system(*)

     

 SpO2/FiO2, mmHg

 ≥ 400

 < 400

 < 315

 < 235 and/or respiratory support

 < 150 with respiratory support

Coagulation

     

 Platelets, /μL

 ≥ 150,000

 < 150,000

 < 100,000

 < 50,000

 < 20,000

Liver function

     

 Bilirubin, mg/dl [μmol/l]

 < 1.2 [20]

1.2–1.9 [20–32]

2.0–5.9 [33–101]

6.0–11.9 [102–204]

 > 12.0 [204]

Cardiovascular system

     

 MAP/PP and adrenergic agents

MAP ≥ 70 mmHg & PP ≥ 20 mmHg

MAP < 70 mmHg or PP < 20 mmHg

PP < 10 mmHg OR dopamine ≤ 5 μg/kg/min or dobutamin (any dose)

Dopamine 5.1-15 μg/kg/min OR epinephrine ≤ 0.1 μg/kg/min OR norepinephrine ≤ 0.1 μg/kg/min

Dopamine > 15 μg/kg/min OR epinephrine > 0.1 μg/kg/min OR norephinephrine > 0.1 μg/kg/min

Central nervous system

     

 Glasgow Coma Scale score

15

13–14

10–12

6–9

 < 6

Renal function

     

 Creatinine, mg/dL

 < 1.2

1.2–1.9

2.0–3.4

3.5–4.9

 > 5.0

 Urine output, mL/d

   

 < 500

 < 200

  1. Bold type indicates a modification of the cardiovascular SOFA parameter to include pulse pressure (PP) (as per WHO dengue shock classification 2009)
  2. FiO2 fraction of inspired oxygen; MAP mean arterial pressure; SpO2 oxygen saturations
  3. (*)This component is adpated form the work of Grissom et al. [14]