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Table 5 Univariate and multivariate analysis of independent predictors for reversion to positive culture

From: Effectiveness and safety of bedaquiline-containing regimens for treatment on patients with refractory RR/MDR/XDR-tuberculosis: a retrospective cohort study in East China

Independent factors Reversion to positive culture Univariate analysis Multivariate analysis
OR (95%CI) p value OR (95%CI) p value
Age    
 < 35 years 5 (6.0)
 35–60 years 15 (15.0) 2.8 (1.0–8.0) 0.05
 ≥ 60 years 1 (5.6) 1.0 (0.1–8.5) 0.94
Type of drug resistance    
 RR 1 (12.5)
 MDR 11 (7.7) 0.6 (0.1–5.2) 0.63
 XDR 9 (17.3) 1.5 (0.2–13.4) 0.73
History of TB treatment (new/previously treated) 2 (10.5)/19 (10.4) 1.0 (0.2–4.7) 0.99
Cavitary disease at baseline (yes/no) 18 (12.9)/3 (5.6) 0.4 (0.1–1.4) 0.14   
Concomitant diabetes (yes/no) 3 (10.3)/18 (10.4) 1.0 (0.3–3.7) 0.99   
Gender (male/female) 20 (13.5)/1 (1.9) 8.1 (1.1–62.1) 0.02 1.2 (0.4–4.1) 0.71
Treatment regimen (bedaquiline/non-bedaquiline) 3 (2.9)/18 (18.0) 0.1 (0.0–0.5) < 0.001 0.1 (0.0–0.5) 0.002*
Regimen containing (BDQ+ Cfz) /Cfz 5 (5.4)/18 (36.0) 0.1(0.0–0.3) < 0.001 0.1 (0. 0–0.4) < 0.001*
Regimen containing (BDQ+ Lzd)/Lzd 5 (5.4)/7(30.4) 0.1 (0.0–0.5) < 0.001 0.1(0.0–0.5) 0.001*
Regimen containing (BDQ+ FQs)/FQs 1(4.3)/19(24.4) 0.1 (0.0–1.1) 0.03 0.00 (–) 1.0
 Regimen containing (BDQ+Cs)/Cs 5 (6.5)/24 (26.4) 0.2 (0.1–0.5) 0.00 0.2(0.0–0.5) 0.001*
BDQ+injectable agents/injectable agents 4(7.4)/21(23.1) 0.3 (0.1–0.8) 0.016 0.1 (0.0–0.5) 0.006*
  1. TB tuberculosis, RR rifampicin-resistant, MDR multidrug-resistant, XDR extensively drug-resistant, 95%CI 95% confidence interval, OR odds ratio
  2. * the differences had statistical significance (p < 0.05)