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Table 6 Incidence of post-treatment Lyme disease syndrome (PTLDS) using different inclusion or outcome criteria, HUMTICK study, Belgium, 2016–2020

From: Non-specific symptoms and post-treatment Lyme disease syndrome in patients with Lyme borreliosis: a prospective cohort study in Belgium (2016–2020)

 

EM patients

DISS patients

PTLDSa/N

Proportion (95% CI)

PTLDSa/N

Proportion (95% CI)

Baseline

6.4/108

5.9 (2.7–12.9)

3.15/15

20.9 (6.8–64.4)

 1: Possible cases included

6.4/113

5.6 (2.6–12.3)

4.15/18

23.0 (9.0–58.8)

 2: Insufficiently treated excludedb

5.4/104

5.2 (2.2–12.2)

3.15/14

22.4 (7.3–69.0)

 3: No standardized questionnaires

9.45/108

8.7 (4.7–16.4)

3.25/15

21.5 (7.0–66.0)

 4: No imputation

6/105

5.7 (2.6–12.4)

3/13

23.1 (8.6–62.3)

  1. EM erythema migrans, DISS disseminated/late Lyme borreliosis, PTLDS post-treatment Lyme disease syndrome, N number, CI confidence interval
  2. aThe decimals in the numbers of PTLDS cases are the result of imputing the outcome in the censored patients, with having PTLDS in only part of the 20 repetitive imputations
  3. bAssessment based on prescribed treatment