Table 1 Outcome definitions in the comparison of patients vs. controls at 6 and 12 months follow-up, HUMTICK study, Belgium, 2016–2020

 New or worsened symptom^a =

 • Regularly present since the previous questionnaire

AND

 • “More severe” compared to pre-Lyme or pre-participation health

AND

 • Worse standardized questionnaire score for symptom present (only for the 6 PTLDS-related symptoms based on SF-36 BP, SF-36 VT or CFQ)

2. Occurrence of any of the 6 PTLDS-related symptoms:

 At least one of the 6 PTLDS-related symptoms new or worsened

 • Defined as above^a

 + Impact daily activities =

 • Limited or strongly limited on the modified GALI

AND

 • At least slight problems with daily activities on the question of the EQ-5D-5L (= level 2–5)