Fig. 1
LB: Lyme borreliosis; CFS: chronic fatigue syndrome; T3: 3 months after diagnosis; T6 and T12: 6 and 12 months after treatment. 1Unexplained or undiagnosed extreme fatigue, widespread musculoskeletal pain or cognitive difficulties. 2Widespread musculoskeletal pain expressed as muscle pain (1) or joint pain (2) at more than one place of the body, fatigue (3), or cognitive difficulties expressed as memory problems (4), difficulties concentrating (5) or problems finding words (6). 3The impact on daily activities had to be present during at least 6 months, but not necessarily start within 6 months. 4Causes explaining the new occurrence or worsening of a symptom reported by the patient as cause for the symptom (e.g. acute diseases, new comorbidities, flare-up of comorbidity already present,…). 5Based on an open question asking to report body parts with pain
Decision tree for defining post-treatment Lyme disease cases following IDSA definition [16].