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Table 4 Analysis of discordant results between APM and BMD UKMYC6 plate methodology

From: Evaluation of the broth microdilution plate methodology for susceptibility testing of Mycobacterium tuberculosis in Peru

Drug

Total

APM

BMD

WGS

APM results supported by WGS (%)

BMD results supported by WGS (%)

S

R

Rifampicin

30

S

R

1

1

22 (73)

8 (27)

  

R

S

7

21

  

Isoniazid

9

S

R

2

1

4 (44)

5 (56)

  

R

S

4

2

  

Ethambutol

49

S

R

0

8

23 (47)

26 (53)

  

R

S

18

23

  

Ethionamide

64

S

R

7

11

29 (45)

35 (55)

  

R

S

24

22

  

Kanamycin

17

S

R

0

0

9 (53)

8 (47)

  

R

S

8

9

  

Levofloxacin

10

S

R

1

2

6 (60)

4 (40)

  

R

S

2

5

  
  1. The genotypic result obtained by WGS is shown. Results with borderline MICs were excluded from the analysis
  2. APM: 7H10 Agar Proportion Method, BMD: Broth Microdilution, WGS: Whole Genome Sequencing, R: Number of resistant strains, S: Number of susceptible strains