Table 1 Drug concentrations values used for comparison between APM and BMD UKMYC6 plate methodology
Drug | APM CC (mg/L) | UKMYC6 ECOFF/ECV (mg/L) | UKMYC6 Borderline (mg/L) | UKMYC6 concentration ranges (mg/L) |
|---|---|---|---|---|
Drugs used in drug-susceptible TB regimens | ||||
Rifampicin | 1.0 | 0.5 | – | 0.03–8 |
Rifabutin | – | 0.12 | – | 0.06–2 |
Isoniazid | 0.2 | 0.1 | 0.2, 0.4 | 0.025–12.8 |
Drugs used in MDR-TB regimensa | ||||
Group A | ||||
Moxifloxacin | – | 1.0 | – | 0.06–4 |
Levofloxacin | 1.0 | 1.0 | – | 0.125–8 |
Bedaquiline | – | 0.25 | – | 0.008–1 |
Linezolid | – | 1.0 | – | 0.06–4 |
Group B | – | |||
Clofazimine | – | 0.25 | – | 0.03–2 |
Group C | ||||
Ethambutol | 5.0 | 4.0 | 4 | 0.25–32 |
Delamanid | – | 0.12 | – | 0.008–0.5 |
Amikacin | – | 1.0 | – | 0.25–16 |
Ethionamide | 5.0 | 4.0 | – | 0.25–8 |
Additional | – | |||
Kanamycin | 5.0 | 4.0 | – | 1–16 |