Table 1 Baseline characteristics of study participants
|  | AmB-D + 5-FC (N = 78) | VCZ + 5FC (N = 28) | AmB-D + Flu (N = 50) | p-value* |
|---|---|---|---|---|
Demographics | Â | Â | Â | Â |
Male—no. (%) | 62 (79.5) | 20 (71.4) | 36 (72) | 0.534 |
Median age (IQR)—years | 42 (34, 52.3) | 41 (34, 51) | 45 (34.8, 57) | 0.568 |
Clinical characteristics | ||||
BMI, mean ± SD | 20.3 ± 2.7 | 19.5 ± 2.5 | 20.4 ± 2.9 | 0.419 |
Median WBC (IQR)—(109/L) | 4.9 (3.5, 6.7) | 4.4 (3, 6.9) | 3.8 (3.2, 5.4) | 0.176 |
Hemoglobin (g/L), mean ± SD | 111.6 ± 20.8 | 105.8 ± 23.8 | 109 ± 18.1 | 0.426 |
Median creatinine level (IQR)—µmol/L | 57.1 (47.7, 66.2) | 66.0 (51.2, 87) | 59.9 (49.3, 72.2) | 0.111 |
Median CD4 + T-cell count (IQR)—cells/µL | 28 (12, 53) | 24 (12.5, 59) | 36 (13, 44.3) | 0.981 |
Current ART use—no. (%) | 14 (17.9) | 7 (25) | 8 (16) | 0.606 |
Receiving TB therapy—no. (%) | 7 (9) | 2 (7.1) | 7 (14) | 0.601†|
Symptoms—no. (%) | ||||
 Headache | 57 (73.1) | 21 (75) | 32 (64) | 0.464 |
 Fever | 55 (70.5) | 19 (67.9) | 31 (62) | 0.604 |
 Nausea | 40 (51.3) | 12 (42.9) | 18 (36) | 0.231 |
 Vomiting | 43 (55.1) | 13 (46.4) | 17 (34) | 0.065 |
 Visual field impairment | 5 (6.4) | 4 (14.3) | 5 (10) | 0.388†|
 Impaired consciousness | 13 (16.7) | 5 (17.9) | 6 (12) | 0.730†|
Opportunistic infection—no. (%) | ||||
 PCP | 6 (7.7) | 1 (3.6) | 1 (2) | 0.443†|
 CMV | 4 (5.1) | 4(14.3) | 7 (14) | 0.152†|
CSF profile | Â | Â | Â | Â |
Median ICP (IQR)—cm H2O | 25 (16, 33) | 25.5 (14, 34.3) | 26.5 (14.5, 40) | 0.856 |
CSF ICP > 25 cm H2O—no. (%) | 37 (47.4) | 14 (50) | 28 (56) | 0.639 |
Median CSF WBC (IQR)—106/L | 23.5 (6, 103) | 3 (0, 58) | 17.5 (9.5, 44.5) | 0.106 |
Median CSF glucose level (IQR)—mmol/L | 2.4 (1.6, 195.7) | 2.6 (1.9, 3.7) | 2.2 (1.2, 3.3) | 0.266 |