Skip to main content

Table 3 Comparison of the clinical outcome of mNGS-positive and -negative group

From: Plasma metagenomic next-generation sequencing of microbial cell-free DNA detects pathogens in patients with suspected infected pancreatic necrosis

  mNGS positive (n = 24) mNGS negative (n = 20) P value
LOS (days) 39 (20.75, 58.75) 23.0 (21, 45) 0.140
ICU admission 21 (87.5%) 15 (75%) 0.436
In-hospital mortality 7 (29.2%) 4 (20.0%) 0.484
Invasive intervention
 Numbers of PCD 2 (1, 3) 0 (0, 1) 0.004
 Requiring of PEN 4 (16.7%) 1 (5.0%) 0.225
 Requiring of ON 8 (33.3%) 1 (5.0%) 0.020
Gastrointestinal fistulas 4 (16.7%) 1 (5.0%) 0.225
Abdominal bleeding 6 (25.0%) 3 (15.0%) 0.413
New-onset sepsis 12 (50.0%) 5 (25.0%) 0.090
New-onset septic shock 12 (50.0%) 4 (20.0%) 0.039
New-onset organ failure 11 (45.8%) 4 (20.0%) 0.072
  1. Data presented as median (interquartile range) or n (%), as appropriate. LOS length of hospital stay, PEN percutaneous endoscopic necrosectomy; PCD percutaneous catheter drainage, ON open necrosectomy