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Table 3 Comparison of the clinical outcome of mNGS-positive and -negative group

From: Plasma metagenomic next-generation sequencing of microbial cell-free DNA detects pathogens in patients with suspected infected pancreatic necrosis

 

mNGS positive (n = 24)

mNGS negative (n = 20)

P value

LOS (days)

39 (20.75, 58.75)

23.0 (21, 45)

0.140

ICU admission

21 (87.5%)

15 (75%)

0.436

In-hospital mortality

7 (29.2%)

4 (20.0%)

0.484

Invasive intervention

 Numbers of PCD

2 (1, 3)

0 (0, 1)

0.004

 Requiring of PEN

4 (16.7%)

1 (5.0%)

0.225

 Requiring of ON

8 (33.3%)

1 (5.0%)

0.020

Gastrointestinal fistulas

4 (16.7%)

1 (5.0%)

0.225

Abdominal bleeding

6 (25.0%)

3 (15.0%)

0.413

New-onset sepsis

12 (50.0%)

5 (25.0%)

0.090

New-onset septic shock

12 (50.0%)

4 (20.0%)

0.039

New-onset organ failure

11 (45.8%)

4 (20.0%)

0.072

  1. Data presented as median (interquartile range) or n (%), as appropriate. LOS length of hospital stay, PEN percutaneous endoscopic necrosectomy; PCD percutaneous catheter drainage, ON open necrosectomy