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Table 1 Baseline characteristics

From: Plasma metagenomic next-generation sequencing of microbial cell-free DNA detects pathogens in patients with suspected infected pancreatic necrosis

 

mNGS positive(n = 24)

mNGS negative(n = 20)

P value

Age (years)

52 (40.25, 62.50)

42.0 (32.0, 58.75)

0.131

Gender (male, %)

18 (75.0%)

13 (65.0%)

0.469

Degree of severity

 Mild

1 (4.2%)

1(5.0%)

0.170

 Moderately severe

2 (8.3%)

6 (30.0%)

 Severe

21(87.5%)

13(65.0%)

Etiology

 Hypertriglyceridemia

9 (37.5%)

11 (55.0%)

0.384

 Gallstone

14 (58.3%)

6 (30.0%)

 Other

1 (4.2%)

3 (15.0%)

APACHE II score

13(10.25, 20.5)

12.50 (7.5, 14)

0.078

SOFA score

4 (2, 7.75)

2 (1.25, 4.75)

0.060

CTSI score

8 (8, 10)

8 (8, 9.5)

0.672

Temperature (°C)

38.8 (38.25, 39.50)

38.45 (38.325, 38.9)

0.143

PCT (μg/L)

1.795 (0.403, 5.155)

0.80 (0.25, 1.67)

0.099

CRP (mg/L)

171.30 (104.38, 240.23)

105.55 (46.70, 153.45)

0.022

Leukocyte (× 109/L)

12.475(7.85, 16.82)

12.07 (7.43, 14.27)

0.396

Neutrophils (× 109/L)

10.75 (9.94, 14.86)

10.26 (6.35, 11.93)

0.525

SIRS

21 (87.5%)

18 (90.0%)

0.589

DM

5 (20.8%)

5 (25.0%)

0.743

Shock

9 (37.5%)

2 (10.0%)

0.036

AKI

8 (33.3%)

3 (15.0%)

0.162

ARDS

13 (54.2%)

7 (35.0%)

0.221

Recurrent AP

3 (12.5%)

1 (5.0%)

0.253

Days from onset (days)

23.5 (19.25, 29.75)

20.0 (14.50, 24.50)

0.158

  1. Data presented as median (interquartile range) or n (%), as appropriate. mNGS metagenomic next-generation sequencing, APACHE II Score acute physiology and chronic health assessment II score, SOFA Score sequential organ failure assessment score, CTSI Score computed tomography severity index score, SIRS systemic inflammatory response syndrome, AKI acute kidney injury, ARDS acute respiratory distress syndrome, PCT procalcitonin, CRP C-reactive protein