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Table 1 Baseline characteristics

From: Plasma metagenomic next-generation sequencing of microbial cell-free DNA detects pathogens in patients with suspected infected pancreatic necrosis

  mNGS positive(n = 24) mNGS negative(n = 20) P value
Age (years) 52 (40.25, 62.50) 42.0 (32.0, 58.75) 0.131
Gender (male, %) 18 (75.0%) 13 (65.0%) 0.469
Degree of severity
 Mild 1 (4.2%) 1(5.0%) 0.170
 Moderately severe 2 (8.3%) 6 (30.0%)
 Severe 21(87.5%) 13(65.0%)
Etiology
 Hypertriglyceridemia 9 (37.5%) 11 (55.0%) 0.384
 Gallstone 14 (58.3%) 6 (30.0%)
 Other 1 (4.2%) 3 (15.0%)
APACHE II score 13(10.25, 20.5) 12.50 (7.5, 14) 0.078
SOFA score 4 (2, 7.75) 2 (1.25, 4.75) 0.060
CTSI score 8 (8, 10) 8 (8, 9.5) 0.672
Temperature (°C) 38.8 (38.25, 39.50) 38.45 (38.325, 38.9) 0.143
PCT (μg/L) 1.795 (0.403, 5.155) 0.80 (0.25, 1.67) 0.099
CRP (mg/L) 171.30 (104.38, 240.23) 105.55 (46.70, 153.45) 0.022
Leukocyte (× 109/L) 12.475(7.85, 16.82) 12.07 (7.43, 14.27) 0.396
Neutrophils (× 109/L) 10.75 (9.94, 14.86) 10.26 (6.35, 11.93) 0.525
SIRS 21 (87.5%) 18 (90.0%) 0.589
DM 5 (20.8%) 5 (25.0%) 0.743
Shock 9 (37.5%) 2 (10.0%) 0.036
AKI 8 (33.3%) 3 (15.0%) 0.162
ARDS 13 (54.2%) 7 (35.0%) 0.221
Recurrent AP 3 (12.5%) 1 (5.0%) 0.253
Days from onset (days) 23.5 (19.25, 29.75) 20.0 (14.50, 24.50) 0.158
  1. Data presented as median (interquartile range) or n (%), as appropriate. mNGS metagenomic next-generation sequencing, APACHE II Score acute physiology and chronic health assessment II score, SOFA Score sequential organ failure assessment score, CTSI Score computed tomography severity index score, SIRS systemic inflammatory response syndrome, AKI acute kidney injury, ARDS acute respiratory distress syndrome, PCT procalcitonin, CRP C-reactive protein