Table 4 Relative sensitivity and specificity of hrHPV DNA PCR (DNA) vs p16(INK4a) IHC (p16), and of DNA and p16(INK4a) vs combined testing (p16 + DNA), to identify a HPV-driven oropharyngeal cancer
Relative | Sensitivity | Specificity |
|---|---|---|
hrHPV DNA vs p16 | 1.04 | 1.00 |
 (95% CI) | (0.97–1.11) | (1.00–1.00) |
p16 + DNA vs p16 | 1.00 | 1.05 |
 (95% CI) | (1.00–1.00) | (0.87–1.26) |
p16 + DNA vs hrHPV DNA | 0.96 | 1.05 |
 (95% CI) | (0.90–1.04) | (0.87–1.26) |