Table 3 Effect sizes and 95% confidence interval (CI) for oxidant/antioxidant, acute phase protein, erythrocytic, hepatological and nephrological variables measured for hosts with mange (Type I and IV hypersensitivity)

Oxidant/antioxidant status

 LPO

5.68 (0.34; 11.02) [4]

2.36 (0.01; 4.72) [3]

4.23 (− 0.52; 8.99) [2]

3.05 (1.57; 4.54) [1]

 SOD

− 4.22 (− 8.99; 0.55) [4]

− 5.82 (− 14.95; 3.31) [7]

− 12.43 (− 31.24; 6.37) [6]

− 1.44 (− 31.24; 6.37) [4]

 CAT

− 2.39 (− 6.58; 1.79) [3]

− 1.34 (− 3.73; 1.05) [6]

− 2.38 (− 4.58; − 0.17) [5]

− 2.48 (− 4.252; − 0.71) [4]

 GSH

− 5.46 (− 10.59; − 0.34) [6]

− 6.56 (− 18.07; 4.94) [5]

− 4.71 (− 9.92; 0.48) [5]

− 3.56 (− 8.35; 1.22) [4]

 GSH:GSSH

–

0.10 (− 0.54; 0.75) [1]

− 0.27 (− 0.93; 0.37) [1]

− 0.83 (− 1.50; − 0.15) [1]

 TOS

2.54 (1.59; 3.49) [1]

0.02 (− 0.62; 0.67) [1]

0.18 (− 0.46; 0.83) [1]

1.64 (0.90; 2.38) [1]

 MDA

− 0.12 (− 0.73; 0.48) [1]

0.41 (− 0.15; 0.97) [2]

1.10 (0.42; 1.77) [2]

1.66 (0.46; 2.87) [1]

 Zinc

− 1.03 (− 1.87; − 0.19) [4]

− 1.79 (− 5.37; 1.77) [2]

− 0.73 (− 1.35; − 0.10) [1]

− 4.14 (− 5.93; − 2.35) [1]

 Copper

− 0.47 (− 0.86; − 0.08) [4]

− 1.03 (− 2.29; 0.23) [4]

− 3.90 (− 10.13; 2.32) [4]

− 3.12 (− 4.62; − 1.61) [1]

 Vitamin C

− 3.52 (− 5.14; − 1.91) [5]

− 1.58 (− 3.36; 0.19) [3]

− 9.72 (− 26.06; 6.60) [2]

− 13.23 (− 35.14; 8.68) [3]

Acute phase protein response

 Ceruloplasmin

1.35 (0.71; 1.99) [1]

–

–

–

 Haptoglobin

0.69 (− 0.07; 1.45) [3]

− 0.36 (− 0.78; 0.05) [1]*

0.52 (− 0.13; 1.18) [1]

 Transferrin

1.87 (1.20; 2.53) [1]

–

–

–

 AGP

0.53 (0.16; 0.90) [1]

0.60 (0.18; 1.01) [1]*

1.14 (0.52; 1.76) [1]

 SAA

68.14 (− 64.55; 200.84) [2]

0.77 (− 0.68; 2.23) [2]

0.64 (− 0.07; 1.36) [1]

1.89 (0.95; 2.83) [1]

 Albumin

− 0.73 (− 1.16; − 0.30) [14]

0.45 (− 1.14; 2.05) [7]

− 1.04 (− 1.87; − 0.21) [5]

− 3.38 (− 6.68; − 0.07) [6]

Erythrocyte changes

 Haemoglobin

− 0.86 (− 1.31; − 0.41) [17]

− 3.07 (− 7.07; 0.92) [6]

− 3.67 (− 8.37; 1.02) [4]

− 3.81 (− 6.74; − 0.88) [5]

 RBC

− 1.32 (− 2.00; − 0.64) [13]

− 0.71 (− 1.06; − 0.36) [7]

− 1.48 (− 2.11; − 0.85) [4]

− 2.42 (− 3.71; − 1.11) [5]

 Haematocrit

− 1.70 (− 2.99; − 0.40) [16]

− 1.98 (− 3.26; − 0.70) [6]

− 3.02 (− 5.99; − 0.04) [4]

− 4.52 (− 9.24; 0.18) [5]

 MCV

− 0.27 (− 1.16; 0.61) [5]

− 0.82 (− 1.45; − 0.18) [3]

− 0.07 (− 0.46; 0.31) [3]

1.51 (0.83; 2.19) [2]

 MCH

0.17 (− 0.30; 0.65) [3]

− 0.23 (− 1.91; 1.44) [2]

− 0.50 (− 1.78; 0.77) [2]

− 0.06 (− 0.97; 0.85) [1]

 MCHC

− 0.11 (− 0.59; 0.36) [3]

− 0.53 (− 4.05; 2.97) [2]

− 0.64 (− 2.08; 0.85) [2]

− 1.51 (− 2.46; − 0.55) [1]

 Iron

− 1.10 (− 2.03; − 0.16) [5]

− 1.23 (− 5.20; 2.74) [2]

0.44 (− 0.64; 1.53) [1]

− 3.69 (− 5.35; − 2.03) [1]

Hepatological and nephrological changes

 Total protein

− 0.80 (− 1.88; 0.27) [16]

− 0.22 (− 0.51; 0.07) [5]

− 0.33 (− 0.92; 0.26) [3]

− 0.76 (− 1.99; 0.47) [4]

 Globulin

0.11 (− 0.57; 0.80) [20]

− 0.17 (− 1.03; 0.67) [1]

0 (− 1.04; 1.04) [1]

− 0.10 (− 1.15; 0.93) [1]

 ALT

1.68 (0.45; 2.90) [6]

2.21 (− 2.75; 7.18) [4]

7.53 (− 7.48; 22.54) [2]

7.31 (− 6.03; 20.65) [4]

 GGT

–

2.95 (− 3.21; 9.11) [2]

11.29 (− 12.33; 34.92) [2]

29.02 (18.58; 39.45) [1]

 Bilirubin

0.79 (− 0.12; 1.72) [6]

0.21 (− 0.40; 0.84) [2]*

1.62 (− 3.50; 6.75) [2]

 BUN

2.06 (− 0.20; 4.32) [4]

0.16 (− 0.99; 1.31) [3]

1.33 (0.36; 2.31) [2]

0.83 (0.41; 1.25) [1]

 Creatinine

1.13 (− 0.98; 3.26) [8]

− 2.57 (− 5.81; 0.65) [6]

− 2.15 (− 5.44; 1.13) [5]

− 4.08 (− 12.17; 4.01) [4]

 BUN:Creatinine

–

1.09 (− 0.03; 2.22) [1]

1.87 (0.64; 3.10) [1]*

 Urea

0.33 (− 1.59; 2.25) [4]

− 2.42 (− 5.19; 0.35) [2]

− 11.51 (− 35.59; 12.56) [2]

− 3.07 (− 11.49; 5.34) [2]

 Urea:Nitrogen

–

–

− 0.59 (− 1.33; 0.14) [1]

0.70 (0.01; 1.38) [1]