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Table 2 Effect sizes and 95% confidence intervals (round parentheses) for immunological parameters measured during sarcoptic mange in hosts exhibiting Type IV hypersensitivity response

From: Evidence underscoring immunological and clinical pathological changes associated with Sarcoptes scabiei infection: synthesis and meta-analysis

Response

Ctrl vs affected

Ctrl vs mild

Ctrl vs moderate

Ctrl vs severe

Leukocytes

0.63 (0.03; 1.23) [6]

1.16 (− 0.11; 2.44) [3]

1.03 (− 1.14; 3.21) [2]

4.14 (− 0.28; 8.56) [3]

Neutrophils

0.71 (− 0.04; 1.47) [11]

0.78 (0.04; 1.52) [4]

0.39 (− 0.38; 1.16) [2]

2.89 (− 0.91; 6.70) [4]

Lymphocytes

− 0.21 (− 1.34; 0.92) [8]

0.41 (− 0.01; 0.83) [4]

0.14 (− 0.24; 0.52) [3]

0.96 (− 0.49; 2.42) [4]

T cells

1.32 (0.01; 2.62) [1]

–

–

–

Monocytes

0.81 (0.20; 1.42) [7]

0.41 (0.05; 0.76) [2]

− 0.07 (− 0.51; 0.66) [1]

1.76 (1.34; 2.18) [2]

Basophils

0.37 (− 0.47; 1.22) [4]

–

–

–

Eosinophils

1.16 (− 0.74; 3.07) [8]

0.76 (0.42; 1.10) [3]

0.42 (− 0.03; 0.88) [2]

0.88 (− 0.83; 2.60) [3]

Mast cells

–

0.71 (− 1.65; 0.21) [1]

0.44 (− 1.16; 0.27) [1]

0.43 (− 1.12; 0.26) [1]

CD4+ 

5.41 (4.51; 6.31) [1]

–

–

–

CD8+ 

5.23 (4.35; 6.11) [1]

–

–

–

MCP-1

5.58 (4.65; 6.52) [1]

–

–

–

IgE

5.04 (− 4.27; 14.35) [2]

–

–

–

IgG

1.33 (0.34; 2.33) [4]

1.73 (− 0.54; 4.00) [3]*

2.81 (0.35; 5.27) [3]

IgA

− 0.63 (− 1.17; − 0.09) [1]

–

–

–

IgM

1.46 (0.87; 2.05) [1]

–

–

–

IL-1

0.00 (− 1.08; 1.08) [5]

–

–

–

IL-6

1.25 (− 2.04; 4.55) [3]

–

–

–

IL-8

− 0.98 (− 2.23; 0.27) [3]

–

–

–

IL-17

27.65 (23.54; 31.76) [1]

–

–

–

TNF-α

0.61 (− 0.70; 1.93) [2]

–

–

 
  1. The number of parameters across studies are provided in square parentheses. A dash represents that no data was available in the category for the given parameter. References for each parameter can be found in Additional file 2: S2
  2. Significant effect sizes (confidence intervals not overlapping zero) are highlighted in bold
  3. Ctrl, control; MCP-1, Monocyte Chemoattractant Protein-1; MMI, macrophage migration inhibitor test; TNF-α, Tumour Necrosis Factor alpha; IL-1, Interleukin-1; IL-5, Interleukin-5; IL-6, Interleukin-6; IL-8, Interleukin-8; IL-17, Interleukin-17; IgG, Immunoglobulin G; IgE, Immunoglobulin E; IgM, Immunoglobulin M; IgA, Immunoglobulin A
  4. *mild/moderate mange disease grouped together in the original article