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Table 1 Effect sizes and 95% confidence intervals (round parentheses) for immunological parameters measured during sarcoptic mange in hosts exhibiting Type I hypersensitivity response

From: Evidence underscoring immunological and clinical pathological changes associated with Sarcoptes scabiei infection: synthesis and meta-analysis

Response

Ctrl vs affected

Ctrl vs mild

Ctrl vs moderate

Ctrl vs severe

Total leukocytes

4.12 (− 1.50; 9.75) [8]

0.75 (− 0.22; 1.72) [2]

0.31 (− 0.76; 1.39) [1]

2.74 (1.33; 4.14) [1]

Lymphocytes

0.18 (− 1.24; 1.61) [8]

0.48 (− 3.12; 4.10) [2]

16.13 (11.99; 20.28) [1]

− 0.02 (− 6.96; 6.91) [2]

Eosinophils

3.84 (0.63; 7.05) [8]

2.48 (1.50; 3.47)  [2]

3.84 (2.64; 5.04) [1]

2.44 (0.88; 3.99) [2]

Mast cells

–

2.28 (1.37; 3.19) [1]

2.79 (1.79; 3.79) [1]

4.18 (2.91; 5.46) [1]

Neutrophils

3.58 (− 1.01; 8.17) [8]

1.53 (0.89; 2.17) [2]

1.63 (0.81; 2.45) [1]

3.01 (2.16; 3.86) [2]

Monocytes

− 0.14 (− 1.03; 0.75) [7]

− 0.08 (− 1.01; 0.83) [1]*

− 0.07 (− 1.07; 0.93) [1]

Basophils

0.41 (− 0.78; 1.61) [3]

–

–

–

Macrophage

–

1.58 (0.77; 2.40) [1]

2.31 (1.39; 3.23) [1]

8.17 (5.98; 10.35) [1]

CD4+ 

− 0.68 (− 1.36; − 0.001) [2]

–

–

–

MCP-1

0.35 (− 0.03; 0.73) [1]

–

–

–

MIP-1a

0.05 (− 0.32; 0.44) [1]

–

–

–

IgE

12.57 (− 8.26; 33.41) [5]

0.98 (0.72; 1.23) [2]

2.43 (2.01; 2.85) [2]

5.10 (0.08; 10.13) [2]

IgG

2.01 (1.10; 2.92) [2]

–

–

–

IgA

− 0.65 (− 1.96; 0.65) [2]

–

–

–

IgM

1.46 (0.98; 1.93) [2]

–

–

–

IL-2

2.39 (1.13; 3.65) [1]

–

–

–

IL-4

5.04 (0.05; 10.04) [3]

–

–

–

IL-5

7.69 (3.80; 11.59) [3]

–

–

–

IL-8

43.80 (− 42.10; 129.71) [2]

–

–

–

IL-10

2.36 (1.67; 3.05) [1]

–

–

–

IL-13

3.39 (2.83; 3.95) [1]

–

–

–

IL-17

0.05 (− 0.33; 0.44) [1]

–

–

–

TNF-α

− 7.26 (− 22.10; 7.57) [2]

–

–

–

TGF-β

9.08 (5.95; 12.20) [1]

–

–

–

IFN-γ

− 0.02 (− 0.41; 0.35) [1]

–

–

–

C3

− 1.98 (− 4.96; 0.99) [2]

–

–

–

  1. The number of parameters across studies are provided in square parentheses. A dash represents that no data was available in the category for the given parameter. References for each parameter can be found in Additional file 2: S2
  2. Significant effect sizes (confidence intervals not overlapping zero) are highlighted in bold
  3. Ctrl, control; MCP-1, Monocyte Chemoattractant Protein-1; MIP-1a, Macrophage Inflammatory Protein-1; IgE, Immunoglobulin E; IgG, Immunoglobulin G; IgA, Immunoglobulin A; IgM, Immunoglobulin M; IL-2, interleukin-2; IL-4, interleukin-4; IL-5, interleukin-5; IL-8, interleukin-8; IL-10, interleukin-10; IL-13, interleukin-13; IL-17, interleukin-17; TNF-α, tumour necrosis factor alpha; TGF-β, Transforming growth factor beta; IFN-γ, Interferon-gamma; C3, Complement 3
  4. *mild/moderate mange disease grouped together in the original article