Non-vaccinated n (%) n = 162 | Vaccinated n (%) n = 88 | p-value | |
---|---|---|---|
Age, median (IQR) | 39 (29–47) | 52 (41–63) | < 0.0001 |
Sex | 0.65 | ||
Male | 73 (45) | 37 (42) | |
Female | 89 (55) | 51 (58) | |
Race/ethnicity | 0.0002 | ||
Hispanic | 68 (42) | 33 (38) | |
Non-Hispanic Black | 69 (43) | 20 (23) | |
Non-Hispanic White | 11 (7) | 20 (23) | |
Asian | 0 (0) | 1 (1) | |
Other | 6 (4) | 5 (6) | |
Unavailable | 8 (5) | 9 (10) | |
BMI | 30 (25–35) | 30 (26–35) | 0.87 |
High-risk co-morbidities per EUA* | |||
BMI ≥ 25 kg/m2 | 115 (71) | 67 (76) | 0.66 |
Pregnancy | 7 (4) | 0 (0) | 0.054 |
Chronic lung disease | 33 (20) | 18 (20) | 0.99 |
Chronic kidney disease | 1 (1) | 5 (6) | 0.0045 |
Diabetes mellitus | 22 (14) | 25 (28) | 0.004 |
Immunocompromised conditions** | 12 (7) | 13 (15) | 0.06 |
Medical-related technological dependence | 1 (1) | 2 (2) | 0.25 |
Neurodevelopmental disorders | 5 (3) | 0 (0) | 0.17 |
Cardiovascular disease or hypertension | 28 (17) | 36 (41) | < 0.0001 |
Number of EUA criteria met | 1 (1–2) | 2 (1–3) | < 0.0001 |
Symptom Duration Prior to Treatment | |||
Days, median (IQR) | 4 (3–6) | 3 (2–5) | 0.02 |
Asymptomatic, n (%) | 0 | 0 | |
Exact days unavailable, n (%) | 0 | 1 (1) | |
Cycle threshold (Ct) values | n = 104 | n = 36 | 0.06 |
< 25 | 70 (67) | 25 (69) | |
Between 25 and 35 | 30 (29) | 6 (17) | |
> 35 | 4 (4) | 5 (14) | |
Days between vaccination and treatment, median (IQR) | |||
Admitted (all-cause 30-day admission) | – | 154 (118–166) | |
Not admitted | – | 160 (133–190) |
Hospitalization | n = 11 | n = 4 | |
---|---|---|---|
Outcomes | |||
All-cause 30-day admission | 11 (7) | 4 (5) | 0.48 |
COVID-19-related 30-day admission | 7 (4) | 1 (1) | 0.27 |
Presenting symptoms at admission | |||
Shortness of breath | 7 (64) | 1 (25) | |
Cough | 3 (27) | 1 (25) | |
Fatigue | 4 (36) | 0 | |
Chest X-ray upon admission | 9 (82) | 3 (75) | |
Requiring supplemental oxygen | 3 (27) | 0 | |
Asymptomatic | 4 (36) | 3 (75) | |
Mild illness | 1 (9) | 0 | |
Moderate illness | 6 (55) | 1 (25) | |
Severe or critically illness | 0 | 0 | |
Lab values on admission (where performed) | |||
White blood cell† (K/uL), median (IQR) | 7.5 (6–8.9) | 8.7 (6–12.6) | |
C-reactive protein†† (mg/dL), median (IQR) | 4.5 (3.2–9.3) | 11.8 (9.5–14.2) | |
D-dimer§ (ug/mL), median (IQR) | 0.56 (0.42–1.2) | 0.66 | |
Fibrinogen§§ (ug/mL), median (IQR) | 456 (384.8–591.8) | 585 | |
Lactic dehydrogenase¶ (U/L), median (IQR) | 284 (232.3–344.8) | 202.5 (198.3–206.8) |