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Table 2 CKRT parameters within 24 h before measuring target concentration in the two groups

From: Continuous infusion versus intermittent infusion of vancomycin in critically ill patients undergoing continuous venovenous hemofiltration: a prospective interventional study

CKRT parameters

II group

(n = 28)

CI group

(n = 23)

Statistics

P

Hematocrit (%), median [IQR]

23.7 (21.0, 27.4)

25.1 (23.2, 29.4)

− 1.570

0.116

Blood flow rate (mL/min), median [IQR]

180.0 (142.5, 180.0)

180.0 (150.0, 180.0)

− 0.909

0.363

Pre-dilution replacement fluid rate (mL/h), median [IQR]

1200.0 (1000.0, 1525.0)

1100.0 (1000.0, 1500.0)

− 1.005

0.315

Post-dilution replacement fluid rate (mL/h), median [IQR]

900.0 (800.0, 1050.0)

1000.0 (900.0, 1050.0)

− 0.836

0.403

Net removal fluid rate (mL/h), median [IQR]

194.0 (107.5, 296.3)

200.0 (100.0, 239.0)

− 0.025

0.980

Input of fluids (mL), median [IQR]

2700.5 (1877.5, 3919.8)

2619.0 (2298.8, 3488.0)

− 0.008

0.993

Output of fluids (mL), median [IQR]

3108.0 (2248.5, 3865.5)

2777.5 (2121.8, 3291.8)

− 1.133

0.257

EFR (mL/kg/h), median [IQR]

37.44 (33.8, 44.7)

35.6 (32.8, 39.9)

− 1.233

0.218

Haemofiltration rate (mL/h), median [IQR]

2290.3 (2038.1, 2763.8)

2161.5 (1937.6, 2588.1)

− 1.159

0.247

SC, mean ± SD

0.65 ± 0.05

0.67 ± 0.04

− 1.007

0.318

CLCVVH (L/h), mean ± SD

2.85 ± 0.38

2.94 ± 0.31

− 0.896

0.374

CLtotal (L/h), mean ± SD

3.42 ± 0.78

3.23 ± 1.08

0.954

0.343

  1. II group intermittent infusion group; CI group continuous infusion group; IQR interquartile range; EFR effluent flow rate; SC sieving coefficient; CLCVVH clearance of vancomycin in CVVH mode; CLtotal clearance of vancomycin