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Table 4 Subgroup analysis for association between HCT-ALB group and outcomes for MIMIC-IV

From: The relationship between hematocrit and serum albumin levels difference and mortality in elderly sepsis patients in intensive care units—a retrospective study based on two large database

  

ICU mortality

Hospital mortality

Subgroups

N

OR (95%CI)

P value

P—interaction

OR (95%CI)

P value

P—interaction

Total

3043

1.41 (1.15, 1.72)

0.001

/

1.26 (1.07, 1.51)

0.007

/

Age

   

0.707

  

0.438

 65–80

2156

1.61 (1.27, 2.05)

 < 0.001

 

1.43 (1.15, 1.746)

0.001

 

 > 80

887

1.14 (0.79, 1.64)

0.473

 

1.01 (0.73, 1.38)

0.964

 

Gender

   

0.189

  

0.051

 Male

1686

1.28 (0.97, 1.68)

0.075

 

1.09 (0.86, 1.38)

0.488

 

 Female

1357

1.64 (1.21, 2.22)

0.001

 

1.54 (1.20, 1.99)

0.001

 

SOFA

   

0.433

  

0.446

 < 6

994

2.37 (1.37, 4.10)

0.002

 

1.56 (1.07, 2.24)

0.018

 

 ≥ 6

2049

1.39 (1.12, 1.71)

0.002

 

1.25 (1.03, 1.52)

0.022

 

BMI

   

0.683

  

0.405

 Underweight

154

1.03 (0.35, 2.94)

0.954

 

1.01 (0.42, 2.39)

0.986

 

 Normalweight

965

8.94 (1.55, 73.6)

0.021

 

2.72 (1.01, 7.25)

0.044

 

 Overweight

876

8.20 (1.51, 58.6)

0.018

 

2.32 (0.94, 5.69)

0.065

 

 Obese

1048

1.23 (0.43, 3.36)

0.689

 

0.84 (0.42, 1.61)

0.609

 

Congestive heart failure

   

0.302

  

0.214

 No

1712

1.25 (0.94, 1.65)

0.119

 

1.13 (0.89, 1.42)

0.324

 

 Yes

1331

1.62 (1.21, 2.18)

0.001

 

1.46 (1.12, 1.89)

0.005

 

Chronic pulmonary disease

   

0.395

  

0.623

 No

2108

1.49 (1.16, 1.91)

0.002

 

1.31 (1.06, 1.61)

0.013

 

 Yes

935

1.28 (0.90, 1.82)

0.162

 

1.20 (0.88, 1.64)

0.254

 

Diabetes

   

0.226

  

0.136

No

1923

1.28 (0.99, 1.64)

0.056

 

1.14 (0.92, 1.42)

0.214

 

Yes

1120

1.75 (1.24, 2.46)

0.001

 

1.54 (1.15, 2.07)

0.004

 

Renal disease

   

0.401

  

0.269

 No

2025

1.32 (1.03, 1.70)

0.027

 

1.16 (0.94, 1.45)

0.179

 

 Yes

1018

1.60 (1.13, 2.26)

0.008

 

1.47 (1.09, 1.98)

0.012

 

Malignant cancer

   

0.758

  

0.072

 No

2428

1.47 (1.17, 1.84)

 < 0.001

 

1.39 (1.15, 1.69)

 < 0.001

 

 Yes

615

1.41 (0.88, 2.24)

0.148

 

0.925 (0.61, 1.39)

0.713

 

Liver disease

   

0.362

  

0.554

 No

2586

1.39 (1.11, 1.73)

0.004

 

1.25 (1.03, 1.51)

0.027

 

 Yes

457

1.73 (1.05, 2.87)

0.031

 

1.46 (0.94, 2.26)

0.091

 

Metastatic solid tumor

   

0.639

  

0.875

 No

2779

1.44 (1.17, 1.79)

 < 0.001

 

1.28 (1.06, 1.53)

0.009

 

 Yes

264

1.28 (0.65, 2.50)

0.464

 

1.36 (0.73, 2.52)

0.328

 
  1. Multivariate models were adjusted by Age, Gender, BMI group, SOFA score, Ventilation, Dialysis, Vasopressor use, Comorbidities (CHF, Chronic Pulmonary Disease, Diabetes, Renal disease, Malignant cancer, Liver disease, and Metastatic solid tumor), excluding models belonging subgroup variate
  2. BMI subgroup were defined as underweight (BMI < 18.5 kg/m2), normal weight (18.5–24.9 kg/m2), overweight (25.0–29.9 kg/m2), and obese (≥ 30.0 kg/m2)
  3. OR odds ratio, CI confidence interval
  4. The OR (95CI%) were calculated when low HCT-ALB (< 6.7) groups set as reference
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BMC Infectious Diseases

ISSN: 1471-2334

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