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Table 4 Subgroup analysis for association between HCT-ALB group and outcomes for MIMIC-IV

From: The relationship between hematocrit and serum albumin levels difference and mortality in elderly sepsis patients in intensive care units—a retrospective study based on two large database

   ICU mortality Hospital mortality
Subgroups N OR (95%CI) P value P—interaction OR (95%CI) P value P—interaction
Total 3043 1.41 (1.15, 1.72) 0.001 / 1.26 (1.07, 1.51) 0.007 /
Age     0.707    0.438
 65–80 2156 1.61 (1.27, 2.05)  < 0.001   1.43 (1.15, 1.746) 0.001  
 > 80 887 1.14 (0.79, 1.64) 0.473   1.01 (0.73, 1.38) 0.964  
Gender     0.189    0.051
 Male 1686 1.28 (0.97, 1.68) 0.075   1.09 (0.86, 1.38) 0.488  
 Female 1357 1.64 (1.21, 2.22) 0.001   1.54 (1.20, 1.99) 0.001  
SOFA     0.433    0.446
 < 6 994 2.37 (1.37, 4.10) 0.002   1.56 (1.07, 2.24) 0.018  
 ≥ 6 2049 1.39 (1.12, 1.71) 0.002   1.25 (1.03, 1.52) 0.022  
BMI     0.683    0.405
 Underweight 154 1.03 (0.35, 2.94) 0.954   1.01 (0.42, 2.39) 0.986  
 Normalweight 965 8.94 (1.55, 73.6) 0.021   2.72 (1.01, 7.25) 0.044  
 Overweight 876 8.20 (1.51, 58.6) 0.018   2.32 (0.94, 5.69) 0.065  
 Obese 1048 1.23 (0.43, 3.36) 0.689   0.84 (0.42, 1.61) 0.609  
Congestive heart failure     0.302    0.214
 No 1712 1.25 (0.94, 1.65) 0.119   1.13 (0.89, 1.42) 0.324  
 Yes 1331 1.62 (1.21, 2.18) 0.001   1.46 (1.12, 1.89) 0.005  
Chronic pulmonary disease     0.395    0.623
 No 2108 1.49 (1.16, 1.91) 0.002   1.31 (1.06, 1.61) 0.013  
 Yes 935 1.28 (0.90, 1.82) 0.162   1.20 (0.88, 1.64) 0.254  
Diabetes     0.226    0.136
No 1923 1.28 (0.99, 1.64) 0.056   1.14 (0.92, 1.42) 0.214  
Yes 1120 1.75 (1.24, 2.46) 0.001   1.54 (1.15, 2.07) 0.004  
Renal disease     0.401    0.269
 No 2025 1.32 (1.03, 1.70) 0.027   1.16 (0.94, 1.45) 0.179  
 Yes 1018 1.60 (1.13, 2.26) 0.008   1.47 (1.09, 1.98) 0.012  
Malignant cancer     0.758    0.072
 No 2428 1.47 (1.17, 1.84)  < 0.001   1.39 (1.15, 1.69)  < 0.001  
 Yes 615 1.41 (0.88, 2.24) 0.148   0.925 (0.61, 1.39) 0.713  
Liver disease     0.362    0.554
 No 2586 1.39 (1.11, 1.73) 0.004   1.25 (1.03, 1.51) 0.027  
 Yes 457 1.73 (1.05, 2.87) 0.031   1.46 (0.94, 2.26) 0.091  
Metastatic solid tumor     0.639    0.875
 No 2779 1.44 (1.17, 1.79)  < 0.001   1.28 (1.06, 1.53) 0.009  
 Yes 264 1.28 (0.65, 2.50) 0.464   1.36 (0.73, 2.52) 0.328  
  1. Multivariate models were adjusted by Age, Gender, BMI group, SOFA score, Ventilation, Dialysis, Vasopressor use, Comorbidities (CHF, Chronic Pulmonary Disease, Diabetes, Renal disease, Malignant cancer, Liver disease, and Metastatic solid tumor), excluding models belonging subgroup variate
  2. BMI subgroup were defined as underweight (BMI < 18.5 kg/m2), normal weight (18.5–24.9 kg/m2), overweight (25.0–29.9 kg/m2), and obese (≥ 30.0 kg/m2)
  3. OR odds ratio, CI confidence interval
  4. The OR (95CI%) were calculated when low HCT-ALB (< 6.7) groups set as reference