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Table 3 Subgroup analysis for association between HCT-ALB group and outcomes for eICU-CRD

From: The relationship between hematocrit and serum albumin levels difference and mortality in elderly sepsis patients in intensive care units—a retrospective study based on two large database

   ICU mortality Hospital mortality
Subgroups N OR (95%CI) P value P—interaction OR (95%CI) P value P—interaction
Total 16,127 1.50 (1.36, 1.65)  < 0.001 / 1.71 (1.58, 1.87)  < 0.001 /
Age     0.390    0.861
 65–80 10,624 1.60 (1.41, 1.80)  < 0.001   1.76 (1.59, 1.96)  < 0.001  
 > 80 5503 1.43 (1.22, 1.69)  < 0.001   1.73 (1.52, 1.98)  < 0.001  
Gender     0.353    0.208
 Male 8607 1.43 (1.25, 1.64)  < 0.001   1.63 (1.46, 1.83)  < 0.001  
 Female 7052 1.57 (1.36, 1.82)  < 0.001   1.82 (1.62, 2.06)  < 0.001  
SOFA     0.064    0.040
 < 6 5592 1.65 (1.29, 2.11)  < 0.001   1.89 (1.59, 2.26)  < 0.001  
  ≥ 6 10,535 1.50 (1.30, 1.67)  < 0.001   1.70 (1.55, 1.68)  < 0.001  
BMI     0.324    0.658
 Underweight 828 1.93 (1.29, 2.91) 0.001   1.86 (1.35, 2.61)  < 0.001  
 Normalweight 5110 1.55 (0.68, 3.60) 0.299   2.00 (1.13, 3.56) 0.017  
 Overweight 4520 1.78 (0.95, 3.35) 0.007   2.32 (1.51, 3.95)  < 0.001  
 Obese 5669 1.91 (1.20, 3.02) 0.006   2.01 (1.45, 2.78)  < 0.001  
Congestive heart failure     0.809    0.499
 No 12,162 1.48 (1.32, 1.66)  < 0.001   1.69 (1.54, 1.86)  < 0.001  
 Yes 3965 1.54 (1.27, 1.88)  < 0.001   1.81 (1.54, 2.14)  < 0.001  
Chronic pulmonary disease     0.753    0.262
 No 12,804 1.49 (1.33, 1.69)  < 0.001   1.68 (1.53, 1.85)  < 0.001  
 Yes 3323 1.56 (1.26, 1.94)  < 0.001   1.87 (1.56, 2.23)  < 0.001  
Diabetes     0.577    0.621
 No 13,409 1.54 (1.39, 1.72)  < 0.001   1.73 (1.53, 1.89)  < 0.001  
 Yes 2718 1.66 (1.33, 2.05)  < 0.001   1.72 (1.38, 2.13)  < 0.001  
Renal disease     0.387    0.206
 No 14,669 1.49 (1.34, 1.65)  < 0.001   1.70 (1.56, 1.85)  < 0.001  
 Yes 1458 1.65 (1.17, 2.32)  < 0.001   1.99 (1.50, 2.66)  < 0.001  
Malignant cancer     0.984    0.721
 No 12,699 1.49 (1.34, 1.67)  < 0.001   1.71 (1.55, 1.88)  < 0.001  
 Yes 3428 1.47 (1.21, 1.81)  < 0.001   1.76 (1.49, 2.09)  < 0.001  
Liver disease     0.735    0.435
 No 15,352 1.50 (1.36, 1.67)  < 0.001   1.71 (1.57, 1.86)  < 0.001  
 Yes 775 1.39 (0.97, 2.01) 0.073   1.99 (1.44, 1.78)  < 0.001  
Metastatic solid tumor     0.953    0.324
 No 15,591 1.50 (1.35, 1.66)  < 0.001   1.70 (1.57,1.86)  < 0.001  
 Yes 536 1.51 (0.92, 2.48) 0.104   2.21 (1.47, 3.34)  < 0.001  
  1. Multivariate models were adjusted by Age, Gender, BMI group, SOFA score, Ventilation, Dialysis, Vasopressor use, Comorbidities (CHF, Chronic Pulmonary Disease, Diabetes, Renal disease, Malignant cancer, Liver disease, and Metastatic solid tumor), excluding models belonging subgroup variate
  2. BMI subgroup were defined as underweight (BMI < 18.5 kg/m2), normal weight (18.5–24.9 kg/m2), overweight (25.0–29.9 kg/m2), and obese (≥ 30.0 kg/m2)
  3. OR odds ratio, CI confidence interval
  4. The OR (95CI%) were calculated when low HCT-ALB (< 6.7) groups set as reference