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Table 4 Pairwise differences in calculated creatinine clearance, calcium, and phosphate at birth for infants in P1084s

From: Maternal and infant renal safety following tenofovir disoproxil fumarate exposure during pregnancy in a randomized control trial

   TDF-ART
(N = 157)
ZDV-ART
(N = 165)
ZDV Alone
(N = 156)
Calculated CrCl (mL/min per 1.73 m2) N 126 128 115
  Mean (sd) 57.4 (22.4) 59.9 (25.9) 62.0 (25.7)
  Mean difference (95% CI) from TDF-ART   − 2.5 (− 8.4, 3.5) − 4.6 (− 10.7, 1.6)
  P value*   0.42  
  Mean difference (95% CI) from ZDV-ART    − 2.1 (− 8.6, 4.4)
Calcium (mg/dL) N 131 136 124
  Mean (sd) 10.30 (1.16) 10.26 (0.91) 10.30 (1.16)
  Mean difference (95% CI) from TDF-ART   0.04 (− 0.22, 0.29) − 0.01 (− 0.29, 0.28)
  Mean difference (95% CI) from ZDV-ART    − 0.04 (− 0.30, 0.21)
Phosphate (mg/dL) N 133 138 125
  Mean (sd) 6.28 (2.79) 6.12 (1.13) 7.32 (8.06)
  Mean difference (95% CI) from TDF-ART   0.16 (− 0.35, 0.68) − 1.04 (− 2.54, 0.46)
  Mean difference (95% CI) from ZDV-ART    − 1.20 (− 2.64, 0.24)
  1. *P value based on t-test assuming unequal variances
  2. CrCl creatinine clearance, TDF tenofovir disoproxil fumarate, ZDV zidovudine, sd standard deviation, CI  confidence interval