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Table 4 Pairwise differences in calculated creatinine clearance, calcium, and phosphate at birth for infants in P1084s

From: Maternal and infant renal safety following tenofovir disoproxil fumarate exposure during pregnancy in a randomized control trial

  

TDF-ART

(N = 157)

ZDV-ART

(N = 165)

ZDV Alone

(N = 156)

Calculated CrCl (mL/min per 1.73 m2)

N

126

128

115

 

Mean (sd)

57.4 (22.4)

59.9 (25.9)

62.0 (25.7)

 

Mean difference (95% CI) from TDF-ART

 

− 2.5 (− 8.4, 3.5)

− 4.6 (− 10.7, 1.6)

 

P value*

 

0.42

 
 

Mean difference (95% CI) from ZDV-ART

  

− 2.1 (− 8.6, 4.4)

Calcium (mg/dL)

N

131

136

124

 

Mean (sd)

10.30 (1.16)

10.26 (0.91)

10.30 (1.16)

 

Mean difference (95% CI) from TDF-ART

 

0.04 (− 0.22, 0.29)

− 0.01 (− 0.29, 0.28)

 

Mean difference (95% CI) from ZDV-ART

  

− 0.04 (− 0.30, 0.21)

Phosphate (mg/dL)

N

133

138

125

 

Mean (sd)

6.28 (2.79)

6.12 (1.13)

7.32 (8.06)

 

Mean difference (95% CI) from TDF-ART

 

0.16 (− 0.35, 0.68)

− 1.04 (− 2.54, 0.46)

 

Mean difference (95% CI) from ZDV-ART

  

− 1.20 (− 2.64, 0.24)

  1. *P value based on t-test assuming unequal variances
  2. CrCl creatinine clearance, TDF tenofovir disoproxil fumarate, ZDV zidovudine, sd standard deviation, CI  confidence interval