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Table 3 Pairwise differences in calcium, phosphate, and hypophosphatemia at delivery for women in the P1084s substudy

From: Maternal and infant renal safety following tenofovir disoproxil fumarate exposure during pregnancy in a randomized control trial

   TDF-ART
(N = 157)
ZDV-ART
(N = 165)
ZDV Alone
(N = 156)
Calcium (mg/dL) N 141 143 137
  Mean (sd) 8.72 (0.60) 8.77 (0.66) 8.78 (0.59)
  Mean difference (95% CI) from TDF-ART   − 0.05 (− 0.20, 0.09) − 0.06 (− 0.20, 0.08)
  Mean difference (95% CI) from ZDV-ART    − 0.01 (− 0.16, 0.14)
Phosphate (mg/dL) N 142 145 137
  Mean (sd) 3.56 (0.60) 3.70 (0.58) 3.72 (0.61)
  Mean difference (95% CI) from TDF-ART   − 0.14 (− 0.28, − 0.01) − 0.17 (− 0.31, − 0.02)
  Mean Difference (95% CI) from ZDV-ART    − 0.02 (− 0.16, 0.12)
Hypophosphatemia No 136/142 (95.77) 143/145 (98.62) 135/137 (98.54)
  Yes 6/142 (4.23) 2/145 (1.38) 2/137 (1.46)
  Mean difference (95% CI) from TDF-ART   2.85 (− 0.97, 6.66) 2.77 (− 1.11, 6.64)
  Mean difference (95% CI) from ZDV-ART    − 0.08 (− 2.84, 2.68)
  1. CrCl creatinine clearance, TDF tenofovir disoproxil fumarate, ZDV zidovudine, sd standard deviation, CI  confidence interval