Table 2 Change in Postpartum Calculated CrCl from Delivery by Postpartum TDF Exposure*
Postpartum TDF exposure | Change in Calculated CrCl (mL/min) | TDF-ART (N = 445) | ZDV-ART (N = 447) | ZDV alone (N = 446) |
|---|---|---|---|---|
Week 6—delivery |  |  |  |  |
 TDF | N | 188 | 207 | 190 |
|  | Mean (95% CI) | − 23.7 (− 29.6, − 17.8) | − 38.6 (− 43.1, − 34.1) | − 38.6 (− 42.6, − 34.5) |
| Â | Mean difference (95% CI) from TDF-ART | Â | 14.9 (7.0, 22.8) | 14.8 (6.7, 23.0) |
 No TDF | N | 199 | 189 | 212 |
|  | Mean (95% CI) | − 12.5 (− 20.1, − 5.0) | − 27.0 (− 31.0, − 23.0) | − 31.7 (− 36.4, − 27.0) |
| Â | Mean difference (95% CI) from TDF-ART | Â | 14.5 (6.5, 22.5) | 19.2 (11.3, 27.0) |
Week 26—delivery |  |  |  |  |
 TDF | N | 192 | 206 | 195 |
|  | Mean (95% CI) | − 17.9 (− 24.8, − 11.1) | − 28.4 (− 34.5, − 22.4) | − 29.3 (− 33.3, − 25.3) |
| Â | Mean difference (95% CI) from TDF-ART | Â | 10.5 (2.1, 18.9) | 11.4 (4.0, 18.7) |
 No TDF | N | 193 | 184 | 188 |
|  | Mean (95% CI) | − 8.6 (− 12.8, − 4.3) | − 19.0 (− 25.7, − 12.3) | − 26.2 (− 31.6, − 20.9) |
| Â | Mean difference (95% CI) from TDF-ART | Â | 10.4 (1.8, 19.1) | 17.7 (10.3, 25.1) |
Week 24—delivery |  |  |  |  |
 TDF | N | 97 | 72 | 75 |
|  | Mean (95% CI) | − 8.4 (− 14.8, − 2.0) | − 30.7 (− 37.2, − 24.1) | − 32.2 (− 42.3, − 22.2) |
| Â | Mean difference (95% CI) from TDF-ART | Â | 22.3 (12.1, 32.5) | 23.9 (12.0, 35.7) |
 No TDF | N | 74 | 86 | 82 |
|  | Mean (95% CI) | − 5.2 (− 13.4, 3.0) | − 16.6 (− 24.6, − 8.6) | − 19.5 (− 29.6, − 9.5) |
| Â | Mean difference (95% CI) from TDF-ART | Â | 11.4 (1.0, 21.8) | 14.3 (2.0, 26.6) |
Week 6—delivery |  |  |  |  |
 TDF | N | 188 | 207 | 190 |
|  | Mean (95% CI) | − 23.7 (− 29.6, − 17.8) | − 38.6 (− 43.1, − 34.1) | − 38.6 (− 42.6, − 34.5) |
| Â | Mean difference (95% CI) from TDF-ART | Â | 14.9 (7.0, 22.8) | 14.8 (6.7, 23.0) |
 No TDF | N | 199 | 189 | 212 |
|  | Mean (95% CI) | − 12.5 (− 20.1, − 5.0) | − 27.0 (− 31.0, − 23.0) | − 31.7 (− 36.4, − 27.0) |
| Â | Mean difference (95% CI) from TDF-ART | Â | 14.5 (6.5, 22.5) | 19.2 (11.3, 27.0) |
Week 26—delivery |  |  |  |  |
 TDF | N | 192 | 206 | 195 |
|  | Mean (95% CI) | − 17.9 (− 24.8, − 11.1) | − 28.4 (− 34.5, − 22.4) | − 29.3 (− 33.3, − 25.3) |
| Â | Mean difference (95% CI) from TDF-ART | Â | 10.5 (2.1, 18.9) | 11.4 (4.0, 18.7) |
 No TDF | N | 193 | 184 | 188 |
|  | Mean (95% CI) | − 8.6 (− 12.8, − 4.3) | − 19.0 (− 25.7, − 12.3) | − 26.2 (− 31.6, − 20.9) |
| Â | Mean difference (95% CI) from TDF-ART | Â | 10.4 (1.8, 19.1) | 17.7 (10.3, 25.1) |
Week 74—delivery |  |  |  |  |
 TDF | N | 97 | 72 | 75 |
|  | Mean (95% CI) | − 8.4 (− 14.8, − 2.0) | − 30.7 (− 37.2, − 24.1) | − 32.2 (− 42.3, − 22.2) |
| Â | Mean difference (95% CI) from TDF-ART | Â | 22.3 (12.1, 32.5) | 23.9 (12.0, 35.7) |
 No TDF | N | 74 | 86 | 82 |
|  | Mean (95% CI) | − 5.2 (− 13.4, 3.0) | − 16.6 (− 24.6, − 8.6) | − 19.5 (− 29.6, − 9.5) |
| Â | Mean difference (95% CI) from TDF-ART | Â | 11.4 (1.0, 21.8) | 14.3 (2.0, 26.6) |