Table 4 Changes in biomarker levels in the study groups

1.05 (0.25–3.65)

1.36 (0.20–6.72)

0.95 (0.18–4.74)

1.05 (0.23–4.48)

0.59 (0.13–1.60)

0.60 (0.16–1.77)

0.49 (0.09–1.59)

0.61 (0.13–2.34)

− 49.71 (− 81.98–3.50)

− 53.81 (− 84.73–9.09)

− 54.77 (− 82.76–29.22)

− 44.73 (− 81.22–14.09)

0.89

− 51.56 (− 82.14–4.85)

− 54.84 (− 84.73–8.10)

− 55.41 (− 83.59–28.60)

− 62.59 (− 84.77–4.12)

0.86

4.95 (1.35–17.45)

5 (1.3–20.6)

6.15 (1.2–27.0)

4.9 (1.2–13)

2.7 (0.75–8.7)

2.8 (0.8–9.6)

2.25 (0.7–6.4)

3.3 (1.2–10.9)

− 27.83 (− 78.91–98.21)

− 40.42 (− 79.86–71.42)

− 53.46 (− 84.29–23.21)

0 (− 66.79–142.46)

0.007

− 27.83 (− 79.71–98.21)

− 40.42 (− 79.86–71.42)

− 51.54 (− 83.08–23.21)

− 16.66 (− 72–120)

0.08

0.006 (0.001–0.007)

0.005 (0.001–0.01)

0.006 (0.001–0.01)

0.005 (0.001–0.007)

0.004 (0.001–0.006)

0.005 (0.001–0.008)

0.004 (0.001–0.006)

0.003 (0.001–0.006)

− 11.98 (− 83.33–40)

0 (− 83.33–50)

− 33.33 (− 83.33–0)

0 (− 83.33–50)

0.55

− 16.66 (− 83.33–40)

0 (− 83.33–40)

− 34.52 (− 83.33–0)

− 24.03 (− 83.33–50)

0.64