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Table 3 Logistic regression analysis showing risk factors for unsuccessful treatment outcome and death versus successful outcome (n = 332) among children diagnosed with TB

From: High burden of childhood tuberculosis in migrants: a retrospective cohort study from the Thailand–Myanmar border

 

Unsuccessful outcome (total n = 374; 42 unsuccessful outcomes vs 332 successful outcomes)*

Death (total n = 347; 15 deaths vs 332 successful outcomes)

n (%)

Crude

Adjusted

n (%)

Crude

Adjusted

OR (95% CI)

p

OR (95% CI)

p

OR (95% CI)

p

OR (95% CI)

p

Sex

 Male

19 (45.2)

Ref.

7 (46.7)

Ref.

 Female

23 (54.8)

1.68 (0.89–3.21)

0.12

1.12 (0.52–2.43)

0.77

8 (53.3)

1.59 (0.56–4.48)

0.38

1.37 (0.43–4.29)

0.60

Age, years

 0–4

21 (50.0)

Ref.

9 (60.0)

Ref.

Ref.

 5–15

21 (50.0)

1.26 (0.66–2.39)

0.41

1.09 (0.51–2.32)

0.83

6 (40.0)

0.84 (0.29–2.41)

0.74

0.65 (0.20–2.12)

0.47

TB site

 PTB

35 (83.3)

Ref.

12 (80.0)

Ref.

 EPTB

7 (16.4)

3.95 (1.52–10.26)

0.005

3.56 (1.12–10.98)

0.03

3 (20.0)

4.94 (1.27–19.26)

0.02

4.26 (0.91–20.61)

0.07

TB history

 New

28 (66.7)

Ref.

12 (80.0)

Ref.

 Retreatment

2 (4.7)

2.30 (0.48–11.02)

0.30

2 (13.3)

5.37 (1.06–27.22)

0.04

 No data

12 (28.6)

1 (6.7)

Bacteriologically + 

 Negative/No data

34 (80.1)

Ref.

11 (73.3)

Ref.

 Yes

8 (19.0)

6.87 (2.58–18.24)

 < 0.001

6.07 (1.68–21.92)

0.01

4 (26.7)

10.61 (2.91–38.65)

 < 0.001

9.31 (1.97–44.03)

0.005

MDR-TB§

 No

40 (95.2)

Ref.

15 (100)

 Yes

2 (4.8)

8.25 (1.13–60.19)

0.04

0.31 (0.01–6.65)

0.45

0

HIV status

 Negative

26 (61.9)

Ref.

9 (60.0)

Ref.

 Positive

5 (11.9)

1.98 (0.71–5.57)

0.19

2.07 (0.69–6.15)

0.19

5 (33.3)

5.74 (1.81–18.29)

0.003

5.95 (1.67–21.22)

0.006

 Unknown

11 (26.2)

42.31 (11.10–161.25)

 < 0.001

42.29 (10.00–178.78)

< 0.001

1 (6.7)

11.11 (1.05–117.48)

0.05

7.31 (0.59–90.00)

0.12

  1. TB tuberculosis, MDR-TB multi-drug resistant TB, HIV human-immunodeficiency virus, OR odds ratio, CI confidence interval
  2. *Reference group excludes children transferred out (n = 24)
  3. Reference group excludes children with unknown mortality status (loss to follow up (n = 26), transfer out (n = 24)) and treatment failure (n = 1)
  4. TB history: variable ‘No data’ excluded from logistic analysis as zero children with no data in comparator group
  5. §MDR-TB excluded from logistic analysis for death as zero children in group