Fig. 4

MDW depends on MIS-C severity and changes through the course of MIS-C diagnosis, treatment, and recovery. A Higher MDW values in MIS-C patients who manifested cardiac complications (Cardiac MIS-C) compared to children with MIS-C without cardiac involvement or presenting with symptoms concerning MIS-C (fever plus recent/current positive SARS-CoV2 PCR or SARS-CoV2 antibodies positive). B ROC in the validation cohort to assess the utility of MDW as a screening tool for cardiac involvement of MIS-C. AUC = area under the curve (fraction). C Blood from children with MIS-C was collected at multiple time points. MDW was plotted by time of collection: at admission, during hospital course, and at discharge or follow-up. Analysis by one way ANOVA. **P < 0.01, ****P < 0.0001. D MDW values from individual patients with MIS-C are plotted over the course of their illness. Black lines connect individual patients with MIS-C. Not all patients provided blood samples at each time point