Variable | Standard therapy (n = 45) | Plasma recipients (n = 46) | P valuea |
---|---|---|---|
Demographics | Â | Â | Â |
Sex (%) | 0.8210 | ||
Female | 14 (31.1) | 13 (28.3) | Â |
Male | 31 (68.9) | 33 (71.7) | Â |
Age (Median—IQR) | 54 (48—59) | 55.5 (38—62.8) | 0.8333 |
BMI (Median—IQR) | 28.2 (26.1—30.5) | 30.9 (27.8—35.2) | 0.0011 |
Therapy (%) | |||
Corticosteroids | 43 (95.6%) | 45 (97.8%) | 0.6166 |
Antibiotics | 22 (48.9%) | 22 (47.8%) | 1.0000 |
NSAIDs | 0 (0.0%) | 1 (2.2%) | 1.0000 |
Heparin | 42 (93.3%) | 45 (97.8%) | 1.0000 |
Clinical characteristics | Â | Â | Â |
WHO scale (%) | Â | Â | 0.8202 |
4 points | 30/44 (68.2) | 32/45 (71.1) | Â |
5 points | 14/44 (31.8) | 13/45 (28.9) | Â |
Log viral load (Estimated mean—SE) | 6.4 (0.57) | 5.63 (0.58) | 1.0000 |
4C Mortality score (Median—IQR) | 6 (5 – 9) | 7 (5.3 – 9) | 0.4850 |
CHOSEN score (Median—IQR) | 17 (16 – 31) | 16.5 (10 – 23.8) | 0.0965 |
SOFA on inclusion (Median—IQR) | 2 (2—2) | 2 (2—2) | 0.3728 |
PaO2-FiO2 on inclusion (Median—IQR) | 182.3 (123—233) | 178 (111.6—249.7) | 0.8728 |
Time from symptoms onset to inclusion (Days—Median—IQR) | 10 (7 – 11) | 10 (8 – 11) | 0.2880 |
Time from symptoms onset to plasma transfusion (Days—Median—IQR) | - | 11 (9 – 12) | - |
Time from hospital admission to plasma transfusion (Days—Median—IQR) | - | 2.5 (2 – 3) | - |
Comorbidities (%) | |||
Hypertension | 10 (22.2) | 13 (28.3) | 0.6308 |
Dyslipidemia | 12 (26.7) | 20 (43.5) | 0.1248 |
Asthma | 3 (6.7) | 1 (2.2) | 0.3610 |
CKD | 3 (6.7) | 2 (4.3) | 0.6768 |
Acid-peptic disease | 13 (28.9) | 9 (19.6) | 0.3357 |
Diabetes | 6 (13.3) | 9 (19.6) | 0.5737 |
Current smoker | 1 (2.2) | 2 (4.3) | 1.0000 |
Former smoker | 19 (42.2) | 20 (43.5) | 1.0000 |
Admission laboratories (Median—IQR) | |||
Platelets × 103 per cubic millimeter | 258 (211—327) | 282 (223—348) | 0.5596 |
Leucocytes | 10,230 (7800—13,960) | 9235 (6922.5—11,540) | 0.0747 |
Lymphocytes | 750 (590—1050) | 985 (752.5—1355) | 0.0080 |
Neutrophils | 9150 (6600—12,500) | 7865 (5667.5—9837) | 0.0354 |
C reactive protein (mg/L) | 78.21 (21.6—121.8) | 49.30 (14.21—111.82) | 0.3718 |
Erythrocyte sedimentation rate (mm/hr) | 30 (13—44) | 25 (15—45) | 0.6984 |
Albumin (g/dL) | 3.5 (3.27—3.74) | 3.40 (3.21—3.68) | 0.2802 |
Total bilirubin (µmol/L) | 0.49 (0.41—0.67) | 0.46 (0.30—0.66) | 0.1387 |
Urea (mg/dL) | 18.9 (14.7 – 22.8) | 15.75 (14.13—23.11) | 0.4436 |
Creatinine (mg/dL) | 0.81 (0.66—0.92) | 0.82 (0.7—0.95) | 0.4506 |
Creatine kinase (U/L) | 80 (47—185) | 93 (50—173.3) | 0.5516 |
D-Dimer (mg/L) | 0.65 (0.33—1.06) | 0.64 (0.45—1.07) | 0.6031 |
Ferritin (ng/mL) | 1199 (727.9—1921) | 1399 (858—2161.5) | 0.6856 |
Lactate dehydrogenase (U/L) | 356 (294—446) | 373.5 (299—441.5) | 0.7002 |
Procalcitonin (ng/mL) | 0.17 (0.11—0.37) | 0.2 (0.10—0.42) | 0.9968 |
Troponin T (ng/mL) | 0.007 (0.003—0.37) | 0.009 (0.005—0.34) | 0.7142 |