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Table 4 Comparison of the changes of liver and kidney function in patients with different Child–Pugh scores in the 3-week group (M (P25–P75))

From: Efficacy and safety of caspofungin for patients with hepatic insufficiency

Group

Time

Albumin

g/L

ALT

U/L

AST

U/L

ALP

U/L

GGT

U/L

TBIL

U/L

Scr

mmol/L

eGFR

mL/min

A

D0

D1

D7

D14

D21

X2

P

31.7 (28–35)

29.5 (27–32)

30.1 (28–32)

30.2 (29–32)

29.5 (29–35)

4.57

0.33

19.0 (8–28)

15.0 (10–43)

16.0 (9–26)

20.0 (9–31)

21.0 (9–38)

0.65

0.96

18.0 (11–25)

19.0 (11–28)

21.0 (13–28)

20.0 (12–28)

27.0 (13–34)

1.48

0.83

72.0 (55–109)

81.0 (58–122)

84.0 (59–114)

82.0 (61–124)

76.0 (67–123)

4.15

0.48

45.0 (23–119)

51.0 (18–129)

36.0 (19–101)

39.0 (26–81)

39.0 (25–56)

1.71

0.79

7.8 (5–18)

7.2 (5–17)

7.6 (5–15)

8.3 (6–13)

8.2 (6–12)

1.21

0.87

78.2 (55–105)

65.7 (54–100)

67.1 (57–108)

62.5 (51–90)

54.7 (45–86)

7.51

0.11

85.5 (31–152)

93.4 (41–142)

83.5 (27–125)

94.0 (37–145)

95.6 (36–146)

8.08

0.08

B

D0

D1

D7

D14

D21

X2

P

28.0 (26–32)

27.1 (26–28)

30.1 (29–32)

31.6 (29–34)#

31.1 (29–33)#

17.26

0.002

15.0 (11–55)

22.0 (8–57)

17.0 (11–48)

25.0 (9–56)

23.5 (13–47)

1.65

0.79

24.0 (14–50)

24.0 (13–76)

22.0 (12–48)

23.0 (10–52)

22.0 (16–32)

3.07

0.45

97.0 (63–140)

106.0 (67–137)

118.0 (71–176)

103.0 (72–201)

86.0 (70–208)

4.61

0.33

67.0 (32–181)

63.1 (26–166)

48.0 (20–178)

87.0 (19–133)

72.0 (23–169)

2.19

0.70

7.7 (6–11)

9.0 (4–12)

9.3 (6–11)

10.6 (8–16)

9.0 (6.1–14)

4.60

0.33

67.9 (51–118)

62.2 (48–118)*

58.9 (45–94)

52.7 (23–71)

53.5 (41–76)

12.54

0.01

70.5 (38–110)

81.4 (42–125)

90.9 (56–133)

99.6 (43–132) *#

106.1 (37–135) *#

11.1

0.02

C

D0

D1

D7

D14

D21

X2

P

29.4 (28–31)

29.6 (29–31)

30.5 (30–32)

31.0 (30–32)

33.0 (32–35)

9.08

0.06

44.0 (16–71)

26.0 (10–52)

18.0 (11–41)

22.0 (11–41)

20.0 (15–40)

1.93

0.75

56.0 (44–159)

56.0 (33–106)

55.0 (41–92)

47.0 (33–63)

55.0 (34–84)

2.94

0.57

145.0 (99–163)

130.0 (116–155)

122.0 (91–157)

121.0 (112–160)

123.0 (92–189)

3.34

0.50

54.0 (30–82)

51.0 (30–68)

41.0 (24–87)

47.0 (31–68)

42.0 (25–70)

1.72

0.79

310.6 (121–400)

276.5 (121–417)

284.5 (110–393)

184.0 (119–358)

171.4 (121–407)

5.49

0.24

60.5 (47–386)

60.5 (54–199)

68.1 (43–114)

53.5 (45–87)

60.1 (42–75)

3.36

0.49

77.8 (14–128)

69.8 (3–128)

96.8 (53–147)

87.4 (47–130)

93.8 (61–116)

3.58

0.46

  1. *Bonferroni's correction, compared with D0, the difference was statistically significant
  2. #Bonferroni's correction, compared with D1, the difference was statistically significant