From: Efficacy and safety of caspofungin for patients with hepatic insufficiency
Group | Time | Albumin g/L | ALT U/L | AST U/L | ALP U/L | GGT U/L | TBIL U/L | Scr mmol/L | eGFR mL/min |
---|---|---|---|---|---|---|---|---|---|
A | D0 D1 D7 D14 D21 X2 P | 31.7 (28–35) 29.5 (27–32) 30.1 (28–32) 30.2 (29–32) 29.5 (29–35) 4.57 0.33 | 19.0 (8–28) 15.0 (10–43) 16.0 (9–26) 20.0 (9–31) 21.0 (9–38) 0.65 0.96 | 18.0 (11–25) 19.0 (11–28) 21.0 (13–28) 20.0 (12–28) 27.0 (13–34) 1.48 0.83 | 72.0 (55–109) 81.0 (58–122) 84.0 (59–114) 82.0 (61–124) 76.0 (67–123) 4.15 0.48 | 45.0 (23–119) 51.0 (18–129) 36.0 (19–101) 39.0 (26–81) 39.0 (25–56) 1.71 0.79 | 7.8 (5–18) 7.2 (5–17) 7.6 (5–15) 8.3 (6–13) 8.2 (6–12) 1.21 0.87 | 78.2 (55–105) 65.7 (54–100) 67.1 (57–108) 62.5 (51–90) 54.7 (45–86) 7.51 0.11 | 85.5 (31–152) 93.4 (41–142) 83.5 (27–125) 94.0 (37–145) 95.6 (36–146) 8.08 0.08 |
B | D0 D1 D7 D14 D21 X2 P | 28.0 (26–32) 27.1 (26–28) 30.1 (29–32) 31.6 (29–34)# 31.1 (29–33)# 17.26 0.002 | 15.0 (11–55) 22.0 (8–57) 17.0 (11–48) 25.0 (9–56) 23.5 (13–47) 1.65 0.79 | 24.0 (14–50) 24.0 (13–76) 22.0 (12–48) 23.0 (10–52) 22.0 (16–32) 3.07 0.45 | 97.0 (63–140) 106.0 (67–137) 118.0 (71–176) 103.0 (72–201) 86.0 (70–208) 4.61 0.33 | 67.0 (32–181) 63.1 (26–166) 48.0 (20–178) 87.0 (19–133) 72.0 (23–169) 2.19 0.70 | 7.7 (6–11) 9.0 (4–12) 9.3 (6–11) 10.6 (8–16) 9.0 (6.1–14) 4.60 0.33 | 67.9 (51–118) 62.2 (48–118)* 58.9 (45–94) 52.7 (23–71) 53.5 (41–76) 12.54 0.01 | 70.5 (38–110) 81.4 (42–125) 90.9 (56–133) 99.6 (43–132) *# 106.1 (37–135) *# 11.1 0.02 |
C | D0 D1 D7 D14 D21 X2 P | 29.4 (28–31) 29.6 (29–31) 30.5 (30–32) 31.0 (30–32) 33.0 (32–35) 9.08 0.06 | 44.0 (16–71) 26.0 (10–52) 18.0 (11–41) 22.0 (11–41) 20.0 (15–40) 1.93 0.75 | 56.0 (44–159) 56.0 (33–106) 55.0 (41–92) 47.0 (33–63) 55.0 (34–84) 2.94 0.57 | 145.0 (99–163) 130.0 (116–155) 122.0 (91–157) 121.0 (112–160) 123.0 (92–189) 3.34 0.50 | 54.0 (30–82) 51.0 (30–68) 41.0 (24–87) 47.0 (31–68) 42.0 (25–70) 1.72 0.79 | 310.6 (121–400) 276.5 (121–417) 284.5 (110–393) 184.0 (119–358) 171.4 (121–407) 5.49 0.24 | 60.5 (47–386) 60.5 (54–199) 68.1 (43–114) 53.5 (45–87) 60.1 (42–75) 3.36 0.49 | 77.8 (14–128) 69.8 (3–128) 96.8 (53–147) 87.4 (47–130) 93.8 (61–116) 3.58 0.46 |