Table 2 Primary and secondary outcomes

WHO scale > 5 or non-rebreather mask at day 29

Number of events by Day 29

250

271

Proportion of participants with an event at Day 29—% (95% CI)

38.5 (34.7–42.3)

41.7 (37.8–45.6)

1.15 (0.91–1.45)

1.33 (1.03–1.72)

Mortality rate at day 29

Number of deaths by Day 29

112

130

Kaplan–Meier estimate of mortality by Day 29—% (95% CI)

19.0 (16.3–23.8)

24.0 (20.9–29.4)

1.18 (0.92–1.52)

1.21 (0.93–1.58)

WHO scale > 5 by day 29

Number of participants with WHO scale > 5 by Day 29

164

179

Kaplan–Meier estimate of WHO scale > 5 by Day 29—% (95% CI)

20.5 (17.0–24.7)

26.2 (22.2–30.8)

1.19 (0.96–1.48)

1.24 (1.00–1.55)

Non-rebreather mask by day 29

Number of participants with non-rebreather mask by Day 29

177

208

Kaplan–Meier estimate of non-rebreather mask by Day 29—% (95% CI)

29.7 (26.0–33.8)

35.2 (31.3–39.5)

1.18 (0.97–1.45)

1.20 (0.98–1.47)

High flow oxygen therapy by day 29*

Number of high flow oxygen therapy by Day 29

201

240

Kaplan–Meier estimate of oxygen therapy by Day 29—% (95% CI)

35.4 (31.3–39.9)

42.1 (37.8–46.6)

1.20 (0.99–1.44)

1.18 (0.98–1.40)

ICU admission by day 29*

Number of ICU admission by Day 29

207

240

Kaplan–Meier estimate of ICU admission by Day 29—% (95% CI)

36.0 (32.0–40.0)

41.7 (37.6–46.1)

1.15 (0.96–1.39)

1.12 (0.93–1.36)

Mechanical ventilation or ECMO by day 29*

Number of Mechanical ventilation or ECMO by Day 29

108

107

Kaplan–Meier estimate of Mechanical ventilation or ECMO by Day 29—% (95% CI)

20.6 (17.0–24.7)

21.5 (17.4–25.7)

0.97 (0.74–1.27)

0.96 (0.73–1.27)

Hospitalization

Median time from symptoms onset to hospitalization (95% CI)—days

6 (5–6)

7 (6–7)

0.93 (0.83–1.04)

0.96 (0.86–1.08)

Median duration on hospitalization (95% CI)—days

11.5 (10–13)

11.0 (10–12)

1.02 (0.88–1.18)

0.95 (0.81–1.10)

Readmission

Number of readmissions after previous discharge

28

19

Kaplan–Meier estimate of re-admission after a discharge—% (95% CI)

5.1 (3.4–7.7)

2.3 (1.2–4.3)

0.68 (0.38–1.23)

(0.42–1.42)