Fig. 1

Contrast-enhanced computed tomography (CT) image, resected specimens, HE staining and immunohistochemical staining (scale bar: 200 µm). A–C Macroscopic aspect of the resected liver. A Cross-sectional imaging CT scanning, presenting cavernous transformation of the portal vein (black arrow). B Preoperative coronal view of CT scans, with compression of the inferior vena cava (black arrow). C Arrows to indicate the necrotic central areas, surrounded by active metacestode area and dense fibrous tissue. D–F HE staining. D Normal appearance of hepatic tissue. E Massive inflammatory cell infiltration in junctional tissue. F Concentric circular texture and extensive fibrous tissue in the lesion (black arrow shows E. multilocularis microcysts). G–I Immunohistochemical staining of nerve fibers (PGP9.5). G Normal liver tissue. H Positive expression observed as yellow or brown staining in the junction (black arrow). I Few nerve fibers within the metacestode infiltrated area (black arrow.)