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Table 3 Univariant and multivariant COX regression model for progression from mild/moderate cases into severe case

From: Predicting progression to severe COVID-19 using the PAINT score

Variables Univariable logistic regression Multivariable logistic regression
OR (95%) p value OR (95%) p value
General information
 Age, > 75 years 1.03 (1.01–1.06) 0.01 3.92 (1.61–9.73) 0.003
 Sex, male 1.494 (1.02–2.184) 0.038 1.67 (0.55–5.09) 0.364
Comorbidities
 Pulmonary disease 3.625 (1.092–12.032) 0.035 11.20 (2.50–49.70) 0.001
 Liver disease 3.304 (1.146–9.527) 0.027 1.27 (0.26–6.34) 0.768
Laboratory findings
 Lymphocyte < 1 × 109/L 0.215 (0.087–0.529) 0.001 0.73 (0.19–2.81) 0.646
 NLR 1.074 (1.012–1.140) 0.019 0.73 (0.19–2.81) 0.646
 AST > 40 U/L 1.008 (1.001–1.020) 0.017 4.60 (1.31–16.00) 0.018
 Urea (mmol/L) 1.066 (1.020–1.115) 0.005 1.92 (0.64–5.71) 0.243
 PT (s) 1.482 (1.042–2.109) 0.029 1.63 (0.63–4.24) 0.315
 Cr > 133 mol/L 1.008 (1.001–1.015) 0.017 2.87 (1.18–6.98) 0.02
 CD4+ T cell (/μL) 0.097 (0.995–0.999) 0.003 0.5 (0.05–5.12) 0.556
 CD8+ T cell (/μL) 0.996 (0.992–0.999) 0.008 1.18 (0.25–5.52) 0.830
 CD3+ T cell (/μL) 0.998 (0.997–0.999) 0.002 2.32 (0.2–27.42) 0.505
 CD19+ T cell (/μL) 0.995 (0.990–0.999) 0.031 1.13 (0.29–4.41) 0.861
 CD16+/CD56+ NK cell (/μL) 0.992 (0.985–0.998) 0.012 3.40 (1.31–9.13) 0.014
 Ig M (g/L) 0.260 (0.072–0.941) 0.040 6.31 (1.99–19.60) 0.002
  1. NLR Neutrophils/Lymphocyte ratio, PT prothrombin time, AST aspartate aminotransferase, Cr creatinine