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Table 5 Characteristics of patients who failed to reach clinical cure on TOC

From: The efficacy of pivmecillinam in oral step-down treatment in hospitalised patients with E. coli bacteremic urinary tract infection; a single-arm, uncontrolled treatment study

Pat. Index

Age (y)

Sex (m/f)

CCI

IDC4

PCT

mcg/L

CRP

mg/L

Lkc

109 × cells/L

Neutrophils

109 × cells/L

Urine culture3

Mecillinam Inhibition-Zone, mm

Ultrasound

Primary end-point

Compliance, skipped doses

Max1

Day 10

Day 17

Max1

Day 10

Day 17

Day 17

Day 17

Day 10

Day 17

Body temp

Health-status

Re-treatment

10

66

m

2

No

11.5

< 0.10

< 0.10

280

66

169

1092

3.4

a

a

26

Normal

36.4

Better

Yes

0

11

62

f

1

No

13.9

< 0.10

< 0.10

225

100

36

8.4

5.0

a

d

23

Normal

37.4

Better

yes

0

27

72

m

0

Yes

17.9

0.20

0.20

315

25

159

6.5

4.6

a

a

27

Normal

37.7

Worse

Yes

0

30

72

f

2

No

5

0.20

527

62

19

Normal

Yes

38

58

f

2

No

0.80

< 0.10

< 0.10

283

5

124

10.6

6.8

d

b

25

Normal

37.6

Worse

Yes

0

45

63

m

1

Yes

1.50

< 0.10

157

13

7

8.5

5.6

a

b

26

Normal

37.1

Worse

No

0

  1. Study treatment pivmecillinam 400 mg QID for 1 week (n = 6)
  2. CCI Charlson Comorbidity Index
  3. 1Maximum value during admission
  4. 2Chronic lymphatic leukemia
  5. 3a =  < 1.000 CFU/mL, b = E. coli > 100.000 CFU/mL, c = Other UT pathogen, d = mixed flora/contaminated
  6. 4Indwelling urinary catheter
  7. 5Not documented