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Table 5 Characteristics of patients who failed to reach clinical cure on TOC

From: The efficacy of pivmecillinam in oral step-down treatment in hospitalised patients with E. coli bacteremic urinary tract infection; a single-arm, uncontrolled treatment study

Pat. Index Age (y) Sex (m/f) CCI IDC4 PCT
mcg/L
CRP
mg/L
Lkc
109 × cells/L
Neutrophils
109 × cells/L
Urine culture3 Mecillinam Inhibition-Zone, mm Ultrasound Primary end-point Compliance, skipped doses
Max1 Day 10 Day 17 Max1 Day 10 Day 17 Day 17 Day 17 Day 10 Day 17 Body temp Health-status Re-treatment
10 66 m 2 No 11.5 < 0.10 < 0.10 280 66 169 1092 3.4 a a 26 Normal 36.4 Better Yes 0
11 62 f 1 No 13.9 < 0.10 < 0.10 225 100 36 8.4 5.0 a d 23 Normal 37.4 Better yes 0
27 72 m 0 Yes 17.9 0.20 0.20 315 25 159 6.5 4.6 a a 27 Normal 37.7 Worse Yes 0
30 72 f 2 No 5 0.20 527 62 19 Normal Yes
38 58 f 2 No 0.80 < 0.10 < 0.10 283 5 124 10.6 6.8 d b 25 Normal 37.6 Worse Yes 0
45 63 m 1 Yes 1.50 < 0.10 157 13 7 8.5 5.6 a b 26 Normal 37.1 Worse No 0
  1. Study treatment pivmecillinam 400 mg QID for 1 week (n = 6)
  2. CCI Charlson Comorbidity Index
  3. 1Maximum value during admission
  4. 2Chronic lymphatic leukemia
  5. 3a =  < 1.000 CFU/mL, b = E. coli > 100.000 CFU/mL, c = Other UT pathogen, d = mixed flora/contaminated
  6. 4Indwelling urinary catheter
  7. 5Not documented