Screening tool | pAUC | Threshold scoreb | Sensitivity (95% CI) | Specificity (95% CI) | NNT |
---|
Z-HRST | 0.76 | 2 | 95.0 (87.5–100) | 53.6  (51.5–55.7) | 26.3 |
Exact logistic | 0.77 | 0.0047 | 95.0 (87.5–100) | 61.4 (59.4–63.6) | 22.0 |
Rescaled logistic | 0.78 | 4 | 95.0 (87.5–100) | 65.6 (63.5–67.6) | 19.7 |
- aOut-of-sample performance of the logistic tools is based on tenfold cross-validation, whereas the value of the partial area under the receiver operating characteristic curve (pAUC) for sensitivity ≥ 80%, sensitivity, specificity and the average number of tests required to find a single HIV-positive child (NNT) is overly optimistic for the Z-HRST (Zimbabwe High-Risk Screening Tool) method
- bSums of affirmative responses for the Z-HRST tool, estimated probability of testing positive for the exact logistic tool, and the sum of the rounded rescaled logistic parameter estimates for the rescaled logistic tool