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Table 3 Correlates of DBS specimens genotyping failure

From: HIV-1 drug resistance genotyping success rates and correlates of Dried-blood spots and plasma specimen genotyping failure in a resource-limited setting

Factor

Genotyping failure n (%)

Odds ratio (95% CI)

p-value

Adjusted OR [aOR (95% CI)]

p-value

Pre-genotyping viral load testing

 Not done

1038/1885 (55.1)

1

< 0.0001

 

0.001

 Done

888/1952 (45.5)

0.68 (0.6–0.77)

 

0.71 (0.16–0.22)

 

Viral load

 1000–10,000 cps/mL

599/897 (66.8)

1

< 0.0001

 

< 0.0001

 > 10,000–50,000 cps/mL

185/497 (37.2)

0.29 (0.23–0.37)

0.3 (0.24–0.38)

 > 50,000–200,000 cps/mL

73/344 (21.2)

0.13 (0.11–0.18)

0.14 (0.10–0.18)

 > 200,000 cps/mL

31/214 (14.5)

0.08 (0.06–0.13)

0.07 (0.06–0.13)

Specimen source

 Research studies

48/137 (35.0)

1

< 0.0001

 

0.006

 Routine clinical diagnosis

1574/3279 (48.0)

1.72 (1.36–2.18)

1.4 (1.11–1.84)

  1. Each denominator represents the number of specimens of that specific category