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Table 3 Medical consultation and health problems 40 to 56 days after boost COVID-19 vaccination

From: Reactogenicity after heterologous and homologous COVID-19 prime-boost vaccination regimens: descriptive interim results of a comparative observational cohort study

 

ChAdOx1/ChAdOx1

ChAdOx1/mRNA

mRNA/mRNA

 

(n = 462)

(n = 1638)

(n = 5004)

Medical consultation, thereof…

69 (14.9%)

287 (17.5%)

796 (15.9%)

Outpatient

   

Yes

61 (88.4%)

248 (86.4%)

667 (83.8%)

Not yet, but planned

6 (8.7%)

36 (12.5%)

117 (14.7%)

No

2 (2.9%)

3 (1.0%)

12 (1.5%)

Inpatient/Clinic

   

Yes

13 (18.8%)

21 (7.3%)

85 (10.7%)

Not yet, but planned

1 (1.4%)

2 (0.7%)

9 (1.1%)

No

55 (79.7%)

264 (92%)

702 (88.2%)

Pre-existing conditions

   

Yes

11 (15.9%)

40 (13.9%)

103 (12.9%)

Partially

22 (31.9%)

95 (33.1%)

291 (36.6%)

No

36 (52.2%)

152 (53%)

402 (50.5%)

Suspected association to vaccination

   

Yes

3 (4.3%)

16 (5.6%)

36 (4.5%)

Partially

10 (14.5%)

60 (20.9%)

171 (21.5%)

No

56 (81.2%)

211 (73.5%)

589 (74.0%)

Perceived affection by the health problems

  

Strongly disagree

6 (8.7%)

24 (8.4%)

72 (9%)

Disagree

7 (10.1%)

38 (13.2%)

88 (11.1%)

Agree

21 (30.4%)

108 (37.6%)

326 (41%)

Strongly agree

35 (50.7%)

117 (40.8%)

310 (38.9%)

Perceived long-term consequences by the health problems

  

Strongly disagree

20 (29.0%)

98 (34.1%)

237 (29.8%)

Disagree

28 (40.6%)

104 (36.2%)

256 (32.2%)

Agree

15 (21.7%)

54 (18.8%)

212 (26.6%)

Strongly agree

6 (8.7%)

31 (10.8%)

91 (11.4%)

 

ChAdOx1/ChAdOx1

ChAdOx1/mRNA

mRNA/mRNA

 

(n = 462)

(n = 1638)

(n = 5004)

Health problems leading to medical consultation, thereof…

   

 Musculoskeletal disorders

35 (7.6%)

123 (7.5%)

321 (6.4%)

 Muscle weakness

5 (1.1%)

14 (0.9%)

44 (0.9%)

 Back pain

14 (3%)

60 (3.7%)

157 (3.1%)

 Pain in extremities

15 (3.2%)

57 (3.5%)

150 (3.0%)

 Joint swelling

5 (1.1%)

19 (1.2%)

42 (0.8%)

 Arthritis

8 (1.7%)

13 (0.8%)

57 (1.1%)

 Subsultus

0 (0%)

14 (0.9%)

33 (0.7%)

 Mobility disorder

7 (1.5%)

15 (0.9%)

61 (1.2%)

 General symptoms

25 (5.4%)

108 (6.6%)

357 (7.1%)

 Flu-like symptoms

5 (1.1%)

36 (2.2%)

105 (2.1%)

 Dyspnoea

4 (0.9%)

10 (0.6%)

55 (1.1%)

 Fever

2 (0.4%)

19 (1.2%)

43 (0.9%)

 Nausea/vomiting

2 (0.4%)

18 (1.1%)

71 (1.4%)

 Abdominal pain

1 (0.2%)

29 (1.8%)

84 (1.7%)

 Fatigue

13 (2.8%)

51 (3.1%)

174 (3.5%)

 Weakness

14 (3.0%)

52 (3.2%)

156 (3.1%)

 Malaise

11 (2.4%)

45 (2.7%)

122 (2.4%)

 Neurological disorders

26 (5.6%)

102 (6.2%)

268 (5.4%)

 Headache

12 (2.6%)

60 (3.7%)

160 (3.2%)

 Dizziness

11 (2.4%)

39 (2.4%)

121 (2.4%)

 Paraesthesia

8 (1.7%)

28 (1.7%)

63 (1.3%)

 Unconsciousness

0 (0%)

1 (0.1%)

6 (0.1%)

 Neuralgia

6 (1.3%)

30 (1.8%)

79 (1.6%)

 Seizure

1 (0.2%)

1 (0.1%)

7 (0.1%)

 Minor stroke

0 (0%)

0 (0%)

4 (0.1%)

 Paralysis

0 (0%)

2 (0.1%)

4 (0.1%)

 Multiple sclerosis

0 (0%)

2 (0.1%)

5 (0.1%)

 Cardiovascular disorders/Risk factors

11 (2.4%)

41 (2.5%)

128 (2.6%)

 Diabetes

5 (1.1%)

4 (0.2%)

19 (0.4%)

 Palpitations

3 (0.6%)

20 (1.2%)

63 (1.3%)

 Chest pain

2 (0.4%)

16 (1.0%)

53 (1.1%)

 Heart attack

0 (0%)

1 (0.1%)

2 (0%)

 Myocarditis

0 (0%)

1 (0.1%)

4 (0.1%)

 Vasculitis

1 (0.2%)

3 (0.2%)

3 (0.1%)

 Pulmonary embolism

0 (0%)

0 (0%)

1 (0%)

 Blood clot

1 (0.2%)

3 (0.2%)

4 (0.1%)

 Coagulation disorder

2 (0.4%)

3 (0.2%)

6 (0.1%)

 Unsolicited health problems

38 (8.2%)

162 (9.9%)

389 (7.8%)

  1. Bold values indicate the number of persons with at least one of the following symptoms in the respective symptom-subgroup
  2. Frequency of medical consultation, health problems and their perception 40 to 56 days after boost COVID-19 vaccination (long-term survey) with ChAdOx1 or mRNA vaccine in cohorts of participants with homologous (mRNA/mRNA or ChAdOx1/ChAdOx1) or heterologous (ChAdOx1/mRNA) prime-boost COVID-19 vaccination regimen who completed the long-term survey. Epilepsy and apoplexy were solicited but not reported by any participant. ChAdOx1: ChAdOx1 (AstraZeneca). mRNA: BNT162b2 (BioNTech/Pfizer) or mRNA-1273 (Moderna)