Table 1 Baseline characteristic of participants with a COVID-19 boost vaccination in a homologous or heterologous regimen

n

487

1943

5715

462

1638

5004

Interval prime-boost (median (IQR) in days)

84 (63–84)

78 (63–84)

42 (42–42)

84 (63–84)

65 (63–84)

42 (42–42)

Age (mean ± SD)

55.87 ± 15.3

47.6 ± 13.89

45.87 ± 15.14

56.69 ± 15.61

45.1 ± 12.52

47.37 ± 15.23

Gender

Male

272 (55.9%)

778 (40.0%)

2428 (42.5%)

257 (55.6%)

448 (27.4%)

2133 (42.6%)

Female

215 (44.1%)

1165 (60.0%)

3281 (57.4%)

205 (44.4%)

1189 (72.6%)

2865 (57.3%)

Diverse

0 (0%)

0 (0%)

6 (0.1%)

0 (0%)

1 (0.1%)

6 (0.1%)

Residence

Rural area¹

181 (37.2%)

597 (30.7%)

1867 (32.7%)

166 (35.9%)

485 (29.6%)

1676 (33.5%)

Small town²

158 (32.4%)

540 (27.8%)

1700 (29.7%)

147 (31.8%)

414 (25.3%)

1540 (30.8%)

Medium-sized town³

60 (12.3%)

236 (12.1%)

694 (12.1%)

59 (12.8%)

193 (11.8%)

607 (12.1%)

City⁴

88 (18.1%)

570 (29.3%)

1454 (25.4%)

90 (19.5%)

546 (33.3%)

1181 (23.6%)

Employment

Employed

293 (60.2%)

1458 (75.0%)

3986 (69.7%)

265 (57.4%)

1347 (82.2%)

3426 (68.5%)

In education

13 (2.7%)

137 (7.1%)

576 (10.1%)

14 (3.0%)

115 (7.0%)

452 (9.0%)

Unemployed

9 (1.8%)

37 (1.9%)

147 (2.6%)

8 (1.7%)

22 (1.3%)

134 (2.7%)

Retired

163 (33.5%)

263 (13.5%)

803 (14.1%)

166 (35.9%)

105 (6.4%)

819 (16.4%)

Other

6 (1.2%)

36 (1.9%)

141 (2.5%)

5 (1.1%)

41 (2.5%)

120 (2.4%)

Not specified

3 (0.6%)

12 (0.6%)

62 (1.1%)

4 (0.9%)

8 (0.5%)

53 (1.1%)

Education

No degree

0 (0%)

0 (0%)

8 (0.1%)

0 (0%)

0 (0%)

8 (0.2%)

Lower certificate

24 (4.9%)

52 (2.7%)

212 (3.7%)

23 (5.0%)

39 (2.4%)

202 (4.0%)

Intermediate certificate

88 (18.1%)

217 (11.2%)

695 (12.2%)

82 (17.7%)

184 (11.2%)

658 (13.1%)

Complete apprenticeship

108 (22.2%)

280 (14.4%)

951 (16.6%)

91 (19.7%)

241 (14.7%)

862 (17.2%)

High school diploma

71 (14.6%)

373 (19.2%)

1066 (18.7%)

66 (14.3%)

347 (21.2%)

918 (18.3%)

University degree

186 (38.2%)

994 (51.2%)

2665 (46.6%)

189 (40.9%)

800 (48.8%)

2249 (44.9%)

Not specified

10 (2.1%)

27 (1.4%)

118 (2.1%)

11 (2.4%)

27 (1.6%)

107 (2.1%)

Health status

No pre-existing diseases

148 (30.4%)

764 (39.3%)

2161 (37.8%)

147 (31.8%)

641 (39.1%)

1792 (35.8%)

Allergies

119 (24.4%)

556 (28.6%)

1629 (28.5%)

115 (24.9%)

520 (31.7%)

1453 (29%)

Hypertension

164 (33.7%)

350 (18%)

1008 (17.6%)

140 (30.3%)

250 (15.3%)

976 (19.5%)

Backpain

83 (17.0%)

269 (13.8%)

831 (14.5%)

84 (18.2%)

250 (15.3%)

754 (15.1%)

Lung Disease

40 (8.2%)

110 (5.7%)

411 (7.2%)

37 (8.0%)

113 (6.9%)

387 (7.7%)

Rheumatism/Autoimmune disease

29 (6.0%)

125 (6.4%)

467 (8.2%)

31 (6.7%)

126 (7.7%)

428 (8.6%)

Depression

24 (4.9%)

90 (4.6%)

413 (7.2%)

25 (5.4%)

86 (5.3%)

359 (7.2%)

Osteoarthritis

43 (8.8%)

125 (6.4%)

324 (5.7%)

42 (9.1%)

97 (5.9%)

311 (6.2%)

Gastrointestinal disease

26 (5.3%)

104 (5.4%)

375 (6.6%)

26 (5.6%)

89 (5.4%)

341 (6.8%)

Heart disease

49 (10.1%)

61 (3.1%)

261 (4.6%)

45 (9.7%)

47 (2.9%)

254 (5.1%)

Diabetes

37 (7.6%)

70 (3.6%)

208 (3.6%)

32 (6.9%)

60 (3.7%)

204 (4.1%)

Cancer

25 (5.1%)

38 (2.0%)

127 (2.2%)

27 (5.8%)

43 (2.6%)

130 (2.6%)

Coagulation problems

11 (2.3%)

32 (1.6%)

144 (2.5%)

10 (2.2%)

41 (2.5%)

138 (2.8%)

Kidney disease

12 (2.5%)

30 (1.5%)

81 (1.4%)

12 (2.6%)

26 (1.6%)

81 (1.6%)

Liver disease

6 (1.2%)

17 (0.9%)

73 (1.3%)

7 (1.5%)

17 (1.0%)

69 (1.4%)

Anaemia

7 (1.4%)

17 (0.9%)

44 (0.8%)

6 (1.3%)

21 (1.3%)

35 (0.7%)

mSCQ-D (median (IQR))⁵

1 (0–2)

0 (0–2)

0 (0–2)

1 (0–2)

0 (0–2)

1 (0–2)

BMI (mean ± SD)⁶

27.0 ± 5.5 (NA⁷ = 7)

25.8 ± 5.2 (NA = 22)

26.1 ± 5.5 (NA = 64)

26.8 ± 5.4 (NA = 7)

25.8 ± 5.7 (NA = 17)

26.2 ± 5.6 (NA = 63)

Participants with other vaccination(s)⁸

30 (6.2%)

135 (6.9%)

456 (8.0%)

23 (5.0%)

97 (5.9%)

389 (7.8%)