Table 4 Risk factors for overall survival
Risk factors | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
HR (95% CI) | P | HR (95% CI) | P | |
Patient age (years) | ||||
< 50 versus ≥ 50 | 0.687 (0.329–1.435) | 0.318 | ||
Stage of underlying disease | ||||
NR versus CR | 2.374 (1.090–5.167) | 0.029 | 1.430 (0.541–3.778) | 0.470 |
Transplant type | ||||
MSD vs HID | 0.876 (0.392–1.959) | 0.747 | ||
Conditioning regimen | ||||
Reduced intensity vs Myeloablative | 1.441 (0.553–3.759) | 0.455 | ||
History of IFD pre-transplant | ||||
No versus yes | 0.794 (0.366–1.724) | 0.560 | ||
CMV disease | ||||
Yes versus no | 1.663 (0.505–5.481) | 0.403 | ||
Acute GVHD | ||||
Grades III–IV versus Grades 0–II | 7.851 (3.785–16.284) | 0.001 | 5.582 (2.297–13.565) | 0.001 |
Chronic GVHD | ||||
Extensive versus no/limited | 0.347 (0.121–0.994) | 0.049 | 0.421(0.141–1.258) | 0.121 |
Post -transplantation IFD | ||||
Yes versus no | 2.082 (0.897–4.836) | 0.088 | 1.035 (0.357–3.007) | 0.949 |
Relapse of underlying primary diseases | ||||
Yes versus no | 6.928 (3.391–14.157) | 0.001 | 3.736 (1.599–8.731) | 0.002 |