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Table 5 Statistically significant latent structure, direct and indirect effects on cognitive QOL

From: Quality of life and associated factors among people receiving second-line anti-retroviral therapy in Johannesburg, South Africa

Latent variables Estimate STD SE P-value
Reasoning → cognitive QOL 1 0.718   
Attention → cognitive QOL 1.902 0.900 0.180 0.000
Forgetfulness → cognitive QOL 1.937 0.635 0.196 0.000
Direct effects
 Pill burden → cognitive QOL − 0.004 − 0.177 0.001 0.005
 Age → cognitive QOL − 0.001 − 0.133 0.006 0.046
 Treatment regimen → cognitive QOL 0.023 0.157 0.009 0.013
 Age → pill burden 0.077 0.192 0.019 0.000
 Treatment regimen → pill burden 0.830 0.130 0.320 0.008
 Severity of adverse events → pill burden 1.775 0.349 0.266 0.000
 Sex → pill burden 1.080 0.158 0.363 0.003
 Sex → adverse events 0.302 0.107 0.124 0.015
 Severity of adverse events → adverse events 1.349 0.642 0.093 0.000
 Sex → alcohol 0.110 0.114 0.056 0.049
Indirect effects
 Age → pill burden → cognitive QOL − 0.0003 − 0.015 0.0001 0.023
 Treatment regimen → pill burden → cognitive QOL − 0.003 − 0.047 0.002 0.050
 Sex → Pill burden → cognitive QOL − 0.004 − 0.019 0.002 0.042
 Severity of adverse events → pill burden → cognitive QOL − 0.007 − 0.005 0.003 0.010
Correlations
 Number of adverse events ↔ pill burden 1.176 0.419 0.258 0.0000