Quality of life and associated factors among people receiving second-line anti-retroviral therapy in Johannesburg, South Africa

Table 5 Statistically significant latent structure, direct and indirect effects on cognitive QOL

Latent variables	Estimate	STD	SE	P-value
Reasoning → cognitive QOL	1	0.718
Attention → cognitive QOL	1.902	0.900	0.180	0.000
Forgetfulness → cognitive QOL	1.937	0.635	0.196	0.000
Direct effects
Pill burden → cognitive QOL	− 0.004	− 0.177	0.001	0.005
Age → cognitive QOL	− 0.001	− 0.133	0.006	0.046
Treatment regimen → cognitive QOL	0.023	0.157	0.009	0.013
Age → pill burden	0.077	0.192	0.019	0.000
Treatment regimen → pill burden	0.830	0.130	0.320	0.008
Severity of adverse events → pill burden	1.775	0.349	0.266	0.000
Sex → pill burden	1.080	0.158	0.363	0.003
Sex → adverse events	0.302	0.107	0.124	0.015
Severity of adverse events → adverse events	1.349	0.642	0.093	0.000
Sex → alcohol	0.110	0.114	0.056	0.049
Indirect effects
Age → pill burden → cognitive QOL	− 0.0003	− 0.015	0.0001	0.023
Treatment regimen → pill burden → cognitive QOL	− 0.003	− 0.047	0.002	0.050
Sex → Pill burden → cognitive QOL	− 0.004	− 0.019	0.002	0.042
Severity of adverse events → pill burden → cognitive QOL	− 0.007	− 0.005	0.003	0.010
Correlations
Number of adverse events ↔ pill burden	1.176	0.419	0.258	0.0000

ISSN: 1471-2334