|
Reasoning → cognitive QOL
|
1
|
0.718
| | |
|
Attention → cognitive QOL
|
1.902
|
0.900
|
0.180
|
0.000
|
|
Forgetfulness → cognitive QOL
|
1.937
|
0.635
|
0.196
|
0.000
|
|
Direct effects
|
|
Pill burden → cognitive QOL
|
− 0.004
|
− 0.177
|
0.001
|
0.005
|
|
Age → cognitive QOL
|
− 0.001
|
− 0.133
|
0.006
|
0.046
|
|
Treatment regimen → cognitive QOL
|
0.023
|
0.157
|
0.009
|
0.013
|
|
Age → pill burden
|
0.077
|
0.192
|
0.019
|
0.000
|
|
Treatment regimen → pill burden
|
0.830
|
0.130
|
0.320
|
0.008
|
|
Severity of adverse events → pill burden
|
1.775
|
0.349
|
0.266
|
0.000
|
|
Sex → pill burden
|
1.080
|
0.158
|
0.363
|
0.003
|
|
Sex → adverse events
|
0.302
|
0.107
|
0.124
|
0.015
|
|
Severity of adverse events → adverse events
|
1.349
|
0.642
|
0.093
|
0.000
|
|
Sex → alcohol
|
0.110
|
0.114
|
0.056
|
0.049
|
|
Indirect effects
|
|
Age → pill burden → cognitive QOL
|
− 0.0003
|
− 0.015
|
0.0001
|
0.023
|
|
Treatment regimen → pill burden → cognitive QOL
|
− 0.003
|
− 0.047
|
0.002
|
0.050
|
|
Sex → Pill burden → cognitive QOL
|
− 0.004
|
− 0.019
|
0.002
|
0.042
|
|
Severity of adverse events → pill burden → cognitive QOL
|
− 0.007
|
− 0.005
|
0.003
|
0.010
|
|
Correlations
|
|
Number of adverse events ↔ pill burden
|
1.176
|
0.419
|
0.258
|
0.0000
|
